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随着人类功能基因组研究的广泛开展,理解基因组中的遗传信息如何协调、有序地调控细胞分化与个体发育的时空过程成为研究的基本问题,阐明这一机制是真核基因表达调控研究的根本任务。基因转录水平的调节是其中的重要环节,诸多顺式作用元件和反式作用因子在不同的发育阶段和不同组织细胞中转录作用模式的差异导致了基因表达的时空特异性。只有利用一定的科学模型和技术手段系
With the extensive research on human functional genomics, understanding how the genetic information in the genome coordinates and orderly regulating the spatiotemporal process of cell differentiation and individual development has become the basic problem of research, and elucidating that this mechanism is the fundamental research of eukaryotic gene expression regulation task. The regulation of gene transcription level is one of the important links. The differences of the transcription patterns of many cis-acting elements and trans-acting factors at different developmental stages and in different tissues and cells lead to the spatiotemporal specificity of gene expression. Only by using certain scientific models and technical means