丹葛止痛方联合硝酸异山梨酯治疗冠状动脉粥样硬化性心脏病心绞痛随机平行对照研究

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[目的]观察丹葛止痛方联合硝酸异山梨酯治疗冠状动脉粥样硬化性心脏病心绞痛疗效。[方法]使用随机平行对照方法,将64例住院患者按住院病志号抽签简单随机分为两组。对照组32例硝酸异山梨酯10mg/次,3次/d,含服。治疗组32例丹葛止痛方:丹参、葛根各12g,枳壳10g,青皮6g,鸡血藤20g,当归、百合、三七各10g,甘草6g,水煎200m L,1剂/d,早晚分服;硝酸异山梨酯治疗同对照组。连续治疗28d为1疗程。观测临床症状、血脂、血液流变学指标、不良反应。治疗1疗程,判定疗效。随访90d观测复发情况。[结果]治疗组显效18例,有效13例,无效1例,总有效率96.00%;对照组显效12例,有效14例,无效6例,总有效率75.00%;治疗组疗效优于对照组(P<0.05)。HDL-C、Cho、LDL-C、TG治疗组均明显改善(P<0.05),对照组无明显变化(P>0.05)。全血高切黏度、全血中切黏度、全血低切黏度、血浆黏度、纤维蛋白原治疗组均明显改善(P<0.05),对照组无明显变化(P>0.05)。[结论]丹葛止痛方联合硝酸异山梨酯治疗冠状动脉粥样硬化性心脏病心绞痛,疗效满意,无严重不良反应,值得推广。 [Objective] To observe the curative effect of Dange Zhitong Recipe combined with isosorbide dinitrate on angina pectoris of coronary atherosclerotic heart disease. [Methods] Using randomized parallel control method, 64 inpatients were randomly divided into two groups randomly according to their hospitalization numbers. Control group, 32 cases of isosorbide dinitrate 10mg / times, 3 times / d, with service. The treatment group, 32 cases of Dange analgesic side: Salvia, Pueraria each 12g, Citrus aurantium 10g, Green skin 6g, Millettia 20g, Angelica, lily, notoginseng 10g, licorice 6g, decoction 200m L, 1 / d, morning and evening Uniforms; isosorbide dinitrate treatment with the control group. Continuous treatment 28d for a course of treatment. Observation of clinical symptoms, blood lipids, blood rheology indicators, adverse reactions. Treatment of a course of treatment to determine the efficacy. Follow-up 90d observation of recurrence. [Result] In the treatment group, 18 cases were markedly effective, 13 cases were effective, 1 case was ineffective, and the total effective rate was 96.00%. In the control group, 12 cases were markedly effective, 14 cases effective, 6 ineffective, and the total effective rate was 75.00% (P <0.05). The levels of HDL-C, Cho, LDL-C and TG in treatment group were significantly improved (P <0.05), but there was no significant difference in control group (P> 0.05). In the control group, there were no significant changes in the control group (P> 0.05) .High shear rate of whole blood, whole blood shear viscosity, whole blood low shear viscosity, plasma viscosity, fibrinogen treatment group were significantly improved (P <0.05). [Conclusion] Dange Zhitong Recipe combined with isosorbide dinitrate in the treatment of angina pectoris of coronary atherosclerotic heart disease has satisfactory curative effect and no serious adverse reactions, which deserves promotion.
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