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醋酸棉酚作为男用节育药的化学研究工作进行了将近10年,以往制备纯醋酸棉酚的熔点基本上都在180℃左右,但国外曾报导为187℃。为进一步搞清楚此问题以及为今后制备醋酸棉酚及制订质量标准创造条件,我们进行了下面的试验。我们曾试用各种不同溶剂和不同量的冰醋酸对醋酸棉酚进行重结晶,发现纯醋酸棉酚的熔点与所使用的溶剂关系不大,但与加入的冰醋酸量有关。通常当加入的冰醋酸量一定时,使用各种不同溶剂结晶,所得醋酸
Gossypol acetic acid was used as a chemical research work for male fertility drugs for nearly 10 years. The melting point of gossypol acetate was almost all around 180°C, but it was reported abroad as 187°C. To further clarify this issue and create conditions for the future preparation of gossypol acetate and the establishment of quality standards, we conducted the following tests. We have tried recrystallization of gossypol acetic acid with various solvents and different amounts of glacial acetic acid. It was found that the melting point of gossypol acetate is not related to the solvent used, but it is related to the amount of acetic acid added. Usually when a certain amount of acetic acid is added, various kinds of solvents are used to crystallize the obtained acetic acid.