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目的了解北京市海淀区新生儿风疹病毒宫内感染情况,评估新生儿脐带血风疹抗体水平,为预防先天性风疹综合征(Congenital Rubella Syndrome,CRS)和控制小月龄儿童风疹发病提供科学依据。方法随机选取在北京市海淀区妇幼保健院分娩的产妇及其新生儿,采用酶联免疫吸附试验方法(ELISA)检测脐带血风疹Ig M和Ig G抗体。结果1 027例新生儿中未检测到CRS和风疹Ig M抗体阳性儿童,脐带血风疹Ig G抗体阳性率为86.56%,几何平均浓度(GMC)为62.16 IU/ml。脐带血风疹抗体水平和阳性率与母亲年龄、风疹疫苗免疫史和风疹患病史差异均有统计学意义。结论开展育龄期妇女风疹疫苗接种是预防先天性风疹综合征和小月龄儿童发病的重要手段。
Objective To understand the intrauterine infection of neonatal rubella virus in Haidian District of Beijing and to evaluate the antibody level of umbilical cord blood rubella in neonates and to provide a scientific basis for preventing Congenital Rubella Syndrome (CRS) and controlling the incidence of rubella in children with small month. Methods Maternal and newborn infants born at Haidian Maternal and Child Health Hospital of Beijing were randomly selected, and antibodies to umbilical cord blood rubella Ig M and Ig G were detected by enzyme linked immunosorbent assay (ELISA). Results No CRS and rubella Ig M antibody positive children were detected in 1 027 newborns. The positive rate of cord blood rubella Ig G antibody was 86.56% and the geometric mean concentration (GMC) was 62.16 IU / ml. Cord blood rubella antibody levels and the positive rate and the mother’s age, rubella vaccine immunization history and history of rubella differences were statistically significant. Conclusion The development of rubella vaccine in women of childbearing age is an important means to prevent the incidence of congenital rubella syndrome and small month-old children.