病毒性疾病严重威胁着人民健康和生命,然而有效的抗病毒药物却为数甚少。抗病毒化学治疗的研究开始于50年代,60年代首次成功地应用thiosemicarbazone (methisazone)治疗天花,以及局部应用疱疹净治疗疱疹性角膜炎。70年代末和80年代初第一种无毒性的抗病毒药物——无环鸟苷问世,对疱疹病毒感染的病人获得较好的疗效。90年代初,由于AIDS病的流行又促进了抗病毒药物的研究和发展。现将目前临床应用的有效抗病毒药物、免疫球蛋白、免疫调节剂及未来展望综述如下。 Viral diseases pose a serious threat to people’s health and lives, yet there are only a handful of effective antiviral drugs. The study of antiviral chemotherapy started in the 1950s. For the first time in the 1960s, thiosemicarbazone (methisazone) was successfully used in the treatment of smallpox and topical application of herpes zoster in the treatment of herpes keratitis. In the late 1970s and early 1980s, the first avirulent antiviral drug, acyclovir, came into being and achieved good results in herpes virus-infected patients. In the early 1990’s, the research and development of antiviral drugs were promoted due to the prevalence of AIDS. The current clinical application of effective anti-viral drugs, immunoglobulins, immunomodulators and future prospects are summarized below.