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1971年,Carson提出痛灭定(tolmetin)具有显著的消炎活性,不久,Wong的药理试验肯定了痛灭定具有安全范围大、疗效高的特点。临床试用发现,本品对类风湿性关节炎、骨关节病、强直性脊椎炎等有良效。本文对痛灭定的疗效与毒性作了较详细的实验研究,并对临床应用作一简要评价。痛灭定由杭州第一制药厂医药工业研究所供应,又名甲苯酰吡咯乙酸,具有下列结构,是种新型的非甾体消炎镇痛药
In 1971, Carson proposed that tolmetin has significant anti-inflammatory activity. Soon, Wong’s pharmacological tests have affirmed that pain relief has a large safety range and high efficacy. Clinical trial found that the goods on rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and other good effect. This article pain curative effect and toxicity made a more detailed experimental study, and clinical application of a brief evaluation. Assume the pain from the first pharmaceutical factory in Hangzhou Institute of Pharmaceutical Industry supply, also known as pamoyl pyrrole acetic acid, has the following structure, is a new type of non-steroidal anti-inflammatory analgesics