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目的对T2DM患者合并发生糖尿病肾病(DN)的危险因素及相关干预进行分析,以为T2DM患者合并发生DN的诊断、治疗提供依据。方法选取95例T2DM患者,其中DN患者(实验组)45例,非DN患者(对照组)50例,对比分析两组收缩压、舒张压、空腹血糖、2 h血糖、空腹胰岛素、餐后胰岛素、尿蛋白排泄率、体重指数、甘油三酯、总胆固醇、糖化血红蛋白、年龄、病程的差异。对比分析实验组内各临床因素。结果实验组的收缩压、舒张压、空腹血糖、餐后2 h血糖、空腹胰岛素、餐后胰岛素、尿蛋白排泄率、体重指数、甘油三酯、总胆固醇、糖化血红蛋白、年龄、病程均明显高于对照组,差异有统计学意义(P<0.05)。实验组内各临床因素对比发现:舒张压、收缩压、空腹血糖、餐后血糖、甘油三酯、空腹胰岛素、餐后胰岛素、病程是T2DM患者DN发病的独立危险因素,其中高血压、高血糖、高胰岛素、高血脂是主要危险因素。结论高血压、高血糖、高胰岛素、高血脂是T2DM患者DN的发病危险因素,针对发病危险因素进行个人生活方式干预具有很高的临床价值。
Objective To analyze the risk factors associated with diabetic nephropathy (DN) and related interventions in patients with T2DM and to provide basis for the diagnosis and treatment of DN associated with T2DM. Methods Ninety-five T2DM patients were selected, including 45 DN patients (experimental group) and 50 non-DN patients (control group). The systolic blood pressure, diastolic blood pressure, fasting blood glucose, fasting blood glucose, fasting insulin, , Urinary protein excretion rate, body mass index, triglyceride, total cholesterol, glycosylated hemoglobin, age, duration of the difference. Comparative analysis of the experimental group of clinical factors. Results The systolic blood pressure, diastolic blood pressure, fasting blood glucose, postprandial 2h blood glucose, fasting insulin, postprandial insulin, urinary protein excretion rate, body mass index, triglyceride, total cholesterol, glycosylated hemoglobin, age and course of disease in experimental group were significantly higher In the control group, the difference was statistically significant (P <0.05). The clinical factors in the experimental group were compared and found: diastolic blood pressure, systolic blood pressure, fasting blood glucose, postprandial blood glucose, triglycerides, fasting insulin, postprandial insulin, duration of disease is an independent risk factor for DN in T2DM patients, including hypertension, hyperglycemia , High insulin, high blood lipids are the main risk factors. Conclusions Hypertension, hyperglycemia, hyperinsulinemia and hyperlipidemia are risk factors of DN in patients with T2DM. It is of high clinical value to carry out personal lifestyle intervention according to risk factors.