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近年来,人们已注意应用水不溶性药物载体对人体特定器官给药。此种给药系统的剂型有脂肪乳剂、脂质体、红细胞影(无色红细胞)、渗透性聚合微囊以及固体微球,所有这些剂型均有各自的局限性。采用粒状微球可能是剂型开发中最有希望的给药系统之一。可溶性人血清白蛋白为血液中生理循环的药物载体,并可在体内降解,因而应用白蛋白微球载体特别受到重视。然而白蛋白微球可引起免疫反应。采用淀粉
In recent years, attention has been paid to the application of water-insoluble drug carriers to specific organs of the human body. The dosage forms for such delivery systems are fat emulsions, liposomes, erythrocytes (leucomatous cells), permeable polymeric microcapsules, and solid microspheres, all of which have their own limitations. The use of granular microspheres may be one of the most promising drug delivery systems in formulation development. Soluble human serum albumin is a physiological and circulatory drug carrier in the blood and can be degraded in vivo. Therefore, the use of albumin microsphere carriers has received special attention. However albumin microspheres can cause an immune response. Using starch