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自然杀伤(natural killer,NK)T细胞是一种同时具有自然杀伤细胞和T细胞部分表型及功能的细胞亚群,能将先天性免疫应答和获得性免疫应答连接起来,限制性识别CD1d-糖脂抗原,并通过调节细胞因子的分泌,影响辅助性T细胞1型(T help cell type1,Th1)/Th2平衡,广泛参与免疫调节。近年研究发现,自然杀伤T细胞对哮喘Th1/Th2失衡及气管高反应(airway hyper responsiveness,AHR)产生起重要作用。本研究就自然杀伤T细胞的特征及其与支气管哮喘关系的最新研究进展,综述如下。
Natural killer (NK) T cells, a subset of cells that have both the natural killer and T cell phenotypes and functions, connect innate and adaptive immune responses and constrain CD1d- It is widely involved in immune regulation by regulating the secretion of cytokines and affecting the balance of T helper cell type 1 (Th1) / Th2. Recent studies have found that natural killer T cells play an important role in the pathogenesis of asthma Th1 / Th2 imbalance and airway hyper responsiveness (AHR). In this study, the characteristics of natural killer T cells and their relationship with bronchial asthma, the latest research progress, are summarized below.