纵向重复测定资料，常规ｔ检验方法不能综合分析各组在时间趋势上的差异，本文介绍裂区设计方差分析方法与多项式曲线模型配合方法。1资料纵向重复测定是指对同一个体在不同的时间点上的反应变量进行的多次测定。这种设计方法在临床药理学研究中应用较广。资料格式如表１。对于 Longitudinal repeated measurement data, conventional t-test method can not be a comprehensive analysis of the differences in the time trend between groups, this article introduces the split zone design analysis of variance and polynomial curve model with the method. 1 Longitudinal and repeated measures of data refer to multiple determinations of response variables of the same individual at different time points. This design method is widely used in clinical pharmacology research. Data format shown in Table 1. for