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异名 Retrovir 化学名 3′-叠氮基-3′-脱氧胸(腺嘧啶核)苷药效分类免疫缺陷病治疗药开发单位 (日本)公司上市厂商 (日本)公司药理本品(AZT)在人免疫缺陷的病毒(HIV)感染细胞内,通过胸苷激酶、胸苷酸激酶的磷酸化作用,形成活化型三磷酸体(AZTTP)。AZTTP竞争性抑制病毒逆转录酶,脱氧胸苷三磷酸代替病毒的DNA,使DNA链中止增长而阻碍病毒繁殖。因为AZTTP对病毒逆转录酶的亲和性比对正常
Synonyms Retrovir Chemical name 3’-azido-3’-deoxythymidine glycosides Pharmacodynamic classification Immunodeficiency disease therapeutic drug Development company (Japan) Company listing Japan Company Pharmacopoeia (AZT) Human immunodeficiency virus (HIV) -infected cells form activated triphosphate (AZTTP) through the phosphorylation of thymidine kinase and thymidylate kinase. AZTTP competitive inhibition of viral reverse transcriptase, deoxythymidine triphosphate instead of the virus DNA, DNA chain stop growth and hinder the virus breeding. Because AZTTP to virus reverse transcriptase affinity than normal