研究不同性质药物葛根素、冰片、梓醇两两包合时的相互影响,探索多组分、多性质的中药复方包合物的包合规律。以HP-β-CD作为包合材料,冷冻干燥法制备包合物。通过包合量测定、DSC和X射线衍射考察葛根素、冰片、梓醇两两包合时的包合情况。结果显示,难溶性药物葛根素和冰片同时包合,当葛根素过量时,葛根素的包合量与单独包合时无明显差异,冰片未被包合;当葛根素量不足而HP-β-CD过量时,冰片才被包合,且包合量低于冰片单独包合。水溶性药物梓醇与葛根素或冰片共同包合时,葛根素或冰片的包合量与单独包合时无明显差异,DSC和X射线衍射图谱均无梓醇的特征峰。难溶性药物葛根素和冰片同时包合时存在竞争,葛根素竞争性更强。水溶性药物梓醇能与HP-β-CD复合但不影响葛根素和冰片的包合。 To study the interaction between puerarin, borneol and catalpol with different properties, and to explore the inclusion law of multi-component and multi-component traditional Chinese medicine inclusion compounds. Using HP-β-CD as the inclusion material, the inclusion compound was prepared by freeze-drying method. The inclusions of puerarin, borneol and catalpol were observed by inclusion amount determination, DSC and X-ray diffraction. The results showed that the insoluble drug puerarin and borneol inclusion at the same time, when the puerarin is excessive, the amount of puerarin inclusion and inclusion alone was no significant difference, borneol was not included; when the amount of puerarin and HP- -CD overdose, borneol was only inclusion, and the inclusion amount is lower than borneol alone inclusion. When the water-soluble drug catalpol and puerarin or borneol were combined together, there was no significant difference between the inclusion amount of puerarin or borneol and that of inclusion alone. There was no characteristic peak of catalpol in DSC and X-ray diffraction patterns. There is competition between the insoluble drug puerarin and borneol, and the puerarin is more competitive. The water-soluble drug catalpol can complex with HP-β-CD but does not affect the inclusion of puerarin and borneol.