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,Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and di
[期刊论文] 作者：Senling Feng,Huifang Zhou,Deyan Wu,Dechong Zheng,Biao Qu,Ruiming Liu,Chen Zhang,Zhe Li,Ying Xie,Hai-Bin,
来源：药学学报（英文版） 年份：2020
Our recent studies demonstrated that the natural product nobiletin (NOB) served as a promising multidrug resistance (MDR) reversal agent and improved the effect...
Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibito
[期刊论文] 作者：Yuncong Yang,Sirui Zhang,Qian Zhou,Chen Zhang,Yuqi Gao,Hao Wang,Zhe Li,Deyan Wu,Yinuo Wu,Yi-You Huang,
来源：药学学报（英文版） 年份：2020
Optimization efforts were devoted to discover novel PDE10A inhibitors in order to improve solubility and pharmacokinetics properties for a long-term therapy aga...
A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-canc
[期刊论文] 作者：Guoyou Xie,Xu-Nian Wu,Yuyi Ling,Yalan Rui,Deyan Wu,Jiawang Zhou,Jiexin Li,Shuibin Lin,Qin Peng,Zigang,
来源：药学学报（英文版） 年份：2022
N6-methyladenosine(m6A)modification is critical for mRNA splicing,nuclear export,stabil-ity and translation.Fat mass and obesity-associated protein(FTO),the first identified m6A demethylase,is critical for cancer progression.Herein,we devel......
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