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Nuclear Translocation and Activation of YAP by Hypoxia Contributes to Chemoresistance of SN38 in Hep
[会议论文] 作者：WANG Dan-dan,ZHOU Tian-yi,CHANG Lin-lin,ZHU Hong,HE Qiao-jun,YANG Bo,
来源：中国药理学会第十三次全国学术大会 年份：2015
Hypoxia was a prominent feature of hepatocellular carcinoma cells (HCC), contributing to therapeutic resistance towards a variety chemotherapeutic agents including Topoisomerase I inhibitor SN38, with...
Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macropha
[会议论文] 作者：LIANG Gui-kai,YAO Zhang-ting,ZHANG Jie-qiong,CHEN Xi,DING Ling,YANG Bo,HE Qiao-jun,
来源：中国药理学会第十三次全国学术大会 年份：2015
Aim Accumulated evidence suggests that M2like polarized tumor associated macrophages (TAMs)plays an important role in cancer progression and metastasis, establishing TAMs, especially M2like TAMs as an...
The E3 ubiquitin protein ligase MDM2 dictates ATRA-induced osteoblastic differentiation of osteosarc
[会议论文] 作者：ZHOU Qian,SHAO Xue-jing,XIAN Miao,LIU Yu-jia,CHEN Xiao-bing,YING Mei-dan,YANG Bo,HE Qiao-jun,
来源：中国药理学会第十三次全国学术大会 年份：2015
Aim Retinoic acid receptor alpha (RARα) plays a critical role in the differentiation process of osteosarcoma cells induced by alltrans retinoic acid (ATRA).However, degradation of RARα through ubiquit...
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