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,A sesquiterpene quinone, dysidine, from the sponge Dysidea villosa, activates the insulin pathway t
[期刊论文] 作者：Yu ZHANG,Yan LI,Yue-wei GUO,Hua-liang JIANG,Xu SHEN,
来源：中国药理学报(英文版) 年份：2009
Aim: The sesquiterpene hydroquinones/quinones belong to one class of marine sponge metabolites, and they have Accepted considerable attention due to their varie...
[期刊论文] 作者：Zhao-bing GAO,Xue-qin CHEN,Hua-liang JIANG,Hong LIU,Guo-yuan HU,
来源：中国药理学报（英文版） 年份：2008
Aim:N,N’-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(4-methyl)-benzenesuifonamide (OMBSA) is a hit compound with potent voltage-gated K+ (Kv) channel-blockin...
[会议论文] 作者：Yu ZHOU,Hong LIU,Dong-xiang LIU,Hua-liang JIANG,Lin-xiang ZHAO,
来源：2007年全国药物化学学术研讨会 年份：2007
...
[会议论文] 作者：Guang-hui DENG,De-ju YE,Lin-yan HE,Hong LIU,Hua-liang JIANG,
来源：2007年全国药物化学学术研讨会 年份：2007
...
[会议论文] 作者：Guang-hui DENG,De-ju YE,Lin-yan HE,Hong LIU,Hua-liang JIANG,
来源：2007年全国药物化学学术研讨会 年份：2007
...
[会议论文] 作者：Yu ZHOU,Hong LIU,Dong-xiang LIU,Lin-xiang ZHAO,Hua-liang JIANG,
来源：2007年全国药物化学学术研讨会 年份：2007
...
[期刊论文] 作者：Ai-jun LU,Zhen-shan ZHANG,Ming-yue ZHENG,Han-jun ZOU,Xiao-min LUO,Hua-liang JIANG,
来源：中国药理学报(英文版) 年份：2007
Aim: To build up a quantitative structure-activity relationship (QSAR) model of20 (S)-camptothecin (CPT) analogs for the prediction of the activity of new CPT a...
Total Synthesis of Gymnorrhizol,an Unprecedented 15-Membered Macrocyclic Polydisulfide from the Chin
[会议论文] 作者：Jing-xu GONG,Xu SHEN,Li-gong YAO,Hua-liang JIANG,Yue-wei GUO,Karsten Krohn,
来源：2007年全国药物化学学术研讨会 年份：2007
...
Total Synthesis of Gymnorrhizol,an Unprecedented 15-Membered Macrocyclic Polydisulfide from the Chin
[会议论文] 作者：Jing-xu GONG,Xu SHEN,Li-gong YAO,Hua-liang JIANG,Karsten Krohn,Yue-wei GUO,
来源：2007年全国药物化学学术研讨会 年份：2007
...
,Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 in
[期刊论文] 作者：Li DU,Ya-xue ZHAO,Liu-meng YANG,Yong-tang ZHENG,Yun TANG,Xu SHEN,Hua-liang JIANG,
来源：中国药理学报(英文版) 年份：2008
Aim:To characterize the functional and pharmacological features of a symmetrical 1-pyrrolidineacetamide,N,N’-(methylene-di-4,1-phenylene) bis-1-pyrrolidineacet...
[期刊论文] 作者：Ting-ting Liu,Teng Yang,Mei-na Gao,Kai-xian Chen,Song Yang,Kun-qian Yu,Hua-liang Jiang,
来源：中国药理学报（英文版） 年份：2019
Serine/threonine phosphatase (Stp1) is a member of the bacterial Mg2+-or Mn2+-dependent protein phosphatase/protein phosphatase 2C family,which is involved in t...
,Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with c
[期刊论文] 作者：Yun-hua KONG,Liang ZHANG,Zheng-yi YANG,Cong HAN,Li-hong HU,Hua-liang JIANG,Xu SHEN,
来源：中国药理学报(英文版) 年份：2008
Aim: To investigate the inhibition features of the natural product juglone (5-hydroxy-1,4-naphthoquinone) against the three key enzymes from Helicobacter pylori...
[期刊论文] 作者：Li-li LIU,Jing LU,Yin LU,Ming-yue ZHENG,Xiao-min LUO,Wei-liang ZHU,Hua-liang JIANG,
来源：中国药理学报（英文版） 年份：2014
...
[会议论文] 作者：Hong LIU,Yong XU,De-iu YE,Jian LI,Min-yue ZHENG,Wei-liang ZHU,Hua-liang JIANG,
来源：2007年全国药物化学学术研讨会 年份：2007
...
[期刊论文] 作者：Hong-xia GUO,Feng WANG,Kun-qian YU,Jing CHEN,Dong-lu BAI,Kai-xian CHEN,Xu SHEN,Hua-liang JIANG,
来源：中国药理学报（英文版） 年份：2005
Aim: To investigate methods for identifying specific cyclophilin D (CypD) inhibitors derived from quinoxaline, thus developing possible lead compounds to inhibi...
[期刊论文] 作者：Yong-tao LI,Li LI,Jing CHEN,Tian-cen HU,Jin HUANG,Yue-wei GUO,Hua-liang JIANG,Xu SHEN,
来源：中国药理学报（英文版） 年份：2009
...
,Pharmacophore-based virtual screening versus docking-based virtual screening: a benchmark compariso
[期刊论文] 作者：Zhi CHEN,Hong-lin LI,Qi-jun ZHANG,Xiao-guang BAO,Kun-qian YU,Xiao-min LUO,Wei-liang ZHU,Hua-liang JIANG,
来源：中国药理学报（英文版） 年份：2009
...
,Molecular dynamics simulations of interaction between protein-tyrosine phosphatase 1B and a bidenta
[期刊论文] 作者：Gui-xia LIU,Jin-zhi TAN,Chun-ying NIU,Jian-hua SHEN,Xiao-min LUO,Xu SHEN,Kai-xian CHEN,Hua-liang JIANG,
来源：中国药理学报（英文版） 年份：2006
Aim: To investigate the dynamic properties of protein-tyrosine phosphatase (PTP)1B and reveal the structural factors responsible for the high inhibitory potency...
,Binding sensitivity of adefovir to the polymerase from different genotypes of HBV: molecular modeli
[期刊论文] 作者：Jing LI,Yun DU,Xian LIU,Qian-cheng SHEN,Ai-long HUANG,Ming-yue ZHENG,Xiao-min LUO,Hua-liang JIANG,
来源：中国药理学报（英文版） 年份：2013
...
,Conformational flexibility of β-secretase: molecular dynamics simulation and essential dynamics ana
[期刊论文] 作者：Bing XIONG,Xiao-qin HUANG,Ling-ling SHEN,Jian-hua SHEN,Xiao-min LUO,Xu SHEN,Hua-liang JIANG,Kai-xian,
来源：中国药理学报（英文版） 年份：2004
AIM: Based on the structural analysis to reveal the mechanism of ligand binding to β-secretase and the specificity of each binding sub-site. METHODS: Molecular...
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