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[会议论文] 作者：Yike Cai,Chenshu Xu,Peiyi Chen,Junqing Hu,Rong Hu,Min Huang,Huichang Bi,
来源：2015广东省药师周大会 年份：2014
Introduction: Monolayers of Caco-2 cells have been widely accepted as one of the well-established in vitro models to predict intestinal drug permeability and absorption in humans.However,the procedure...
Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and sen
[期刊论文] 作者：Huizhen Zhang,Yongtao Wang,Lihuan Guan,Yixin Chen,Panpan Chen,Jiahong Sun,Frank J.Gonzalez,Min Huang,Huichang Bi,
来源：药物分析学报:英文版 年份：2021
Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C(CPT1C), a mitocho......
Lipidomics reveals carnitine palrnitoyltransferase 1C protects cancer cells from lipotoxicity and se
[期刊论文] 作者：Huizhen Zhang,Yongtao Wang,Lihuan Guan,Yixin Chen,Panpan Chen,Jiahong Sun,Frank J.Gonzalez,Min Huang,Huichang Bi,
来源：药物分析学报（英文版） 年份：2021
Lipotoxicity,caused by intracellular lipid accumulation,accelerates the degenerative process of cellular senescence,which has implications in cancer development...
Low dose of oleanolic acid protects against lithocholic acid-induced cholestasis in mice:potential i
[会议论文] 作者：Pan Chen,Hang Zeng,Yongtao Wang,Xiaomei Fan,Chenshu Xu,Rongrong Deng,Xunian Zhou,Huichang Bi,Min Huang,
来源：2015广东省药师周大会 年份：2014
Oleanolic acid (OA) is a natural triterpenoid and has been demonstrated to protect against varieties of hepatotoxicants.However recently,OA at high doses was reported to produce apparent cholestasis i...
,Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-ind
[期刊论文] 作者：Xi Li,Chenshu Xu,Fulin Jiang,Yufei Mo,Xiaomei Fan,Yaoting Li,Yiming Jiang,Dongshun Li,Min Huang,Huichang Bi,
来源：药学学报（英文版） 年份：2017
Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet (WZ),a preparation of extract from Schisandra sphena...
[会议论文] 作者：Deng,Chenshu Xu,Xiao Chen,Pan Chen,Yongtao Wang,Xunian Zhou,Jing Jin,Lu Niu,Mengjia Ying,Min Huang,Huichang Bi,
来源：2015广东省药师周大会 年份：2014
The pregnane X receptor (PXR,NR1I2),a member of the nuclear receptor (NR) superfamily,is activated by a number of clinically prescribed drugs and herbal extracts.The inducible expression of several im...
Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-as
[期刊论文] 作者：Yiming Jiang,Xinpeng Yao,Shuguang Zhu,Xiao Yang,Ruimin Wang,Jianing Tian,Frank J.Gonzalez,Min Huang,Huichang Bi,
来源：药学学报（英文版） 年份：2021
The constitutive androstane receptor(CAR,NR3I1)belongs to nuclear receptor superfamily.It was reported that CAR agonist TCPOBOP induces hepatomegaly but the und...
[期刊论文] 作者：Dongyang Liu,Xiangyu Hou,Lan Tang,Xin Wang,Yuanfeng Lyu,Xiaoyan Chen,Kexin Liu,Ai-Ming Yu,Zhong Zuo,Huichang Bi,
来源：药学学报（英文版） 年份：2019
Pharmacokinetics (PK) is the study of the absorption,distribution,metabolism,and excretion (ADME) processes of a drug.Understanding PK properties is essential f...
SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting
[期刊论文] 作者：Wenzhou Li,Panpan Chen,Yiming Jiang,Jiahong Sun,Yixin Chen,Pan Chen,Lihuan Guan,Yajie Wen,Min Huang,Huichang Bi,
来源：药学学报（英文版） 年份：2021
Acetaminophen(APAP)overdose is the leading cause of drug-induced liver injury,and its prognosis depends on the balance between hepatocyte death and regeneration...
[会议论文] 作者：Jiahong Sun,Kaili Fu,Lihuan Guan,Huizhen Zhang,Yiming Jiang,Xi Li,Xuezhen Zeng,Xiao Chen,Min Huang,Huichang Bi,
来源：2018第23届广东省药师周大会 年份：2017
BACKGROUND AND PURPOSE: Tumor suppressor p53 is traditionally recognized as a surveillance molecule to preserve genome integrity.Recent studies have emerged on discovering its functions in metabolic d...
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