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Targeting PRMT5 confers elimination of chronic myelogenous leukemia stem cells in combination with i
[会议论文] 作者：Jingxuan Pan,
来源：2016医学科学前沿暨第四届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2016
Leukemia stem cells(LSCs)insensitive to imatinib are believed to be responsible for resistance to BCR-ABL tyrosine kinase inhibitors and relapse of chronic...
[会议论文] 作者：Qi Cao,Jingxuan Pan,
来源：第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议 年份：2014
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Novel thiazole amine class tyrosine kinase inhibitors induce apoptosis in human mast cells expressin
[会议论文] 作者：Yanli Jin,Jingxuan Pan,
来源：第八届中国肿瘤学术大会暨抗癌药物专业委员会中青年论坛 年份：2014
Objective: Gain-of-function mutations of receptor tyrosine kinase KIT play a critical role in the pathogenesis of systemic mastocytosis (SM) and gastrointestinal stromal tumors.D816V KIT mutation, fou...
[会议论文] 作者：Qi Cao,Jingxuan Pan,
来源：第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议 年份：2014
...
Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal m
[会议论文] 作者：jingfeng Zhou,Jingxuan Pan,
来源：2019中国肿瘤学大会 年份：2019
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,Inhibitory effect of pyrvinium pamoate on uveal melanoma cells involves blocking of Wnt/β-catenin p
[期刊论文] 作者：Lei Zheng,Yizhi Liu,Jingxuan Pan,
来源：生物化学与生物物理学报（英文版） 年份：2017
Uveal melanoma is the most common primary intraocular malignancy in adults.And there is an absence of targeted agents for patients with uveal melanoma.Pyrvinium...
SAHA and PJ 1548,a Novel Tyrosine Kinase Inhibitor Synergistically Induce Apoptosis in Imatinib-Resi
[会议论文] 作者：Qiangui Bu,Ke Ding,Jingxuan Pan,
来源：2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2012
Limited treatment options are available for chronic myeloid leukemia (CML) patients who develop imatinib mesylate resistance particularly in patients with gatekeep mutant Bcr-Abl such as T3151.Compoun...
Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekee
[会议论文] 作者：Yanli Jin,Ke Ding,Jingxuan Pan,
来源：2015医学前沿论坛暨第十四届全国肿瘤药理与化疗学术会议 年份：2015
Objective Like T315I Bcr-Abl, T674I FIP1L1-PDGFRα existed in a subset of chronic eosinophilic leukemia (CEL) is also gatekeeper mutation that is resistant to tyrosine kinase inhibitors (TKIs, e.g., im...
,Everolimus enhances the cytotoxicity of bendamustine in multiple myeloma cells through a network of
[期刊论文] 作者：Bo Lu,Juan Li,Jingxuan Pan,Beihui Huang,Junru Liu,Dong Zheng,
来源：生物化学与生物物理学报（英文版） 年份：2013
...
Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor α
[会议论文] 作者：Yongbin Wu,Bei Jin,Xianping Shi,Xiaoyong Sun,Ke Ding,Jingxuan Pan,
来源：2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2012
Purpose:The "gate-keeper" mutations T6741 PDGFRα in hypereosinophilic syndrome (HES) and T3151 Bcr-Abl in chronic myeloid leukemia (CML),are resistant to imatinib and the second-generation small molec...
Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekee
[会议论文] 作者：Yanli Jin,Ke Ding,Honglin Li,Mengzhu Xue,Xiaoke Shi,Chengyan Wang,Jingxuan Pan,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
Background: Like T315I Bcr-Abl, T674I FIP1L1-PDGFRα existed in a subset of chronic eosinophilic leukemia (CEL) is also gatekeeper mutation that is resistant to tyrosine kinase inhibitors (TKIs, e.g.,...
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