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New findings of frataxin function and regulation implication on the pathological mechanism of Friedr
[会议论文] 作者：Kuanyu Li,
来源：第一届生物微量元素研讨会 年份：2012
Frataxin (FXN),a highly conserved protein from bacteria to humans,is important in the biogenesis of iron-sulfur clusters (ISC),prosthetic groups allowing essent...
[会议论文] 作者：Kuanyu Li,
来源：2013第三届内分泌与代谢大会暨2013第二届糖尿病大会 年份：2013
Friedreich ataxia (FRDA) is an inherited neurodegenerative disease caused by frataxin (FXN) deficiency due to the insertion of GAA triplet repeats within the first intron of FXN gene.FXN, a highly con...
Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental su
[会议论文] 作者：Huiying Yan,Kuanyu Li,
来源：第二届中国国际生物微量元素大会 年份：2014
Previous studies have shown that iron accumulation is involved in the pathogenesis of brain injury following subarachnoid hemorrhage [SAH] and blockage of m...
The interplay between frataxin deficiency and hypoxia response may be implicated in pathology of Fri
[会议论文] 作者：Xiaoyan Sun,Kuanyu Li,
来源：第二届中国国际生物微量元素大会 年份：2014
Frataxin (FXN) is a mitochondrial protein that is involved in mitochondrial iron homeostasis and iron-sulfur cluster biogenesis.Defective expression of FXN...
[会议论文] 作者：Shuangying Hao,Kuanyu Li,
来源：第一届生物微量元素研讨会 年份：2012
Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by reduced expression levels of the frataxin gene (FXN) due to expansion of...
Putative expression mechanism of the novel transcripts of human frataxin,causing neurodegenerative d
[会议论文] 作者：Xiaoman Dai,Kuanyu Li,
来源：第十四届国际人与动物微量元素大会 年份：2011
...
Putative pathological mechanism of neurodegenrative disease Friedreich ataxia,caused by frataxin def
[会议论文] 作者：Kuanyu Li,Xiaoman Dai,Tracey Rouault,
来源：第十四届国际人与动物微量元素大会 年份：2011
...
Putative pathological mechanism of neurodegenrative disease Friedreich ataxia,caused by frataxin def
[会议论文] 作者：Kuanyu Li,Xiaoman Dai,Tracey Rouault,
来源：第十四届国际人与动物微量元素大会 年份：2011
...
[会议论文] 作者：Huihui Li,Xiaoyan Sun,Hongting Zhao,Kuanyu Li,
来源：The 6th FAONS Congress and 11th Biennial Conference of CNS(第 年份：2015
Frataxin(FXN)is a mitochondrial protein that is involved in mitochondrial iron homeostasis and iron-sulfur cluster biogenesis.Defective expression of FXN causes an autosomal recessive mitochondrial di...
[期刊论文] 作者：Wenxin Zhang,Li Xu,Hongting Zhao,Kuanyu Li,
来源：生物物理学报 年份：2021
As a cofactor,iron-sulfur (Fe-S) cluster binds to proteins or enzymes that play important roles in vari-ous important biological processes,including DNA synthes...
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