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[期刊论文] 作者：Liwu Fu,,
来源：Acta Pharmaceutica Sinica B 年份：2016
In this special issue of Research Progress of Anti-Cancer Drugs,articles describing the current advances of research on anti-cancer drugs will be invited for su...
[期刊论文] 作者：Liwu Fu,,
来源：Acta Pharmaceutica Sinica B 年份：2017
The research for antitumor therapeutics is a timeless topic and keeps pace with times,especially chemotherapy and target therapy.Drug target identification is a...
Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10
[会议论文] 作者：hui zhang,Liwu Fu,
来源：第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议 年份：2014
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Linsitinib (0SI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10
[会议论文] 作者：hui zhang,Liwu Fu,
来源：第八届中国肿瘤学术大会暨抗癌药物专业委员会中青年论坛 年份：2014
Objective: Linsitinib, a novel dual insulin-like growth factor 1 (IGF-1R)/insulin receptor (IR) kinase inhibitor in phase Ⅲ clinical trial, was investigate...
[期刊论文] 作者：Lihua Huang,Liwu Fu,,
来源：Acta Pharmaceutica Sinica B 年份：2015
Since the discovery that non-small cell lung cancer(NSCLC) is driven by epidermal growth factor receptor(EGFR) mutations, the EGFR tyrosine kinase inhibitors(EG...
The role of ALDH2 in tumorigenesis and tumor progression:Targeting ALDH2 as a potential cancer treat
[期刊论文] 作者：Hong Zhang,Liwu Fu,
来源：药学学报（英文版） 年份：2021
A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde dehydrogenase 2 (ALDH2).The correlation between ALDH2 dysfunction and tumorigenesis/growth/metastasis has been widely reported.Either low or high ALDH2......
Linsitinib (0SI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10
[会议论文] 作者：hui zhang,Liwu Fu,
来源：第八届中国肿瘤学术大会暨抗癌药物专业委员会中青年论坛 年份：2014
Objective: Linsitinib, a novel dual insulin-like growth factor 1 (IGF-1R)/insulin receptor (IR) kinase inhibitor in phase Ⅲ clinical trial, was investigated the reversal of multidrug resistance (MDR)...
Elevated Expression of Plasma Membrane Ca2+ channel Orai1 and Intracellular Ca2+ Oscillations Contri
[会议论文] 作者：Hui Zhang,Liwu Fu,
来源：2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 年份：2014
Objective: Largely due to the fact that most of patients suffering from ESCC are diagnosed at advanced states, the 5-year survival rate is merely 19%, which is the fourth worst among all cancers.Thus,...
Cancer cells were transiently protected from chemotherapeutical agent via instant intercellular tran
[会议论文] 作者：Xiaokun Wang,Liwu Fu,
来源：广东省药理学会第七届2015学术交流大会 年份：2015
Intercellular exchange of membrane proteins through various incompletely defined mechanisms is a novel cellular cross-talk.Recently,the intercellular transfer of ABCB1 between tumor cells has been pro...
Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10
[会议论文] 作者：hui zhang,Liwu Fu,
来源：第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议 年份：2014
...
CEP-33779antagonizes P-glycoprotein mediated multidrug resistance by inhibiting its transport functi
[会议论文] 作者：shangjun tang,liwu fu,weiqiang chen,
来源：第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议 年份：2014
...
CEP-33779 antagonizes P-glycoprotein mediated multidrug resistance by inhibiting its transport funct
[会议论文] 作者：shangjun tang,liwu fu,weiqiang chen,
来源：第八届中国肿瘤学术大会暨抗癌药物专业委员会中青年论坛 年份：2014
...
p38γ MAPK promotes pancreatic tumorigenesis by stimulating PFKFB3/Glut2-dependent aerobic glycolysis
[会议论文] 作者：Fang wang,Guan Chen,Liwu Fu,
来源：2019中国肿瘤学大会 年份：2019
Objective BACKGROUND & AIMS: Cancer cells rely on aerobic glycolysis to generate ATP for autonomous growth,a phenomenon termed “the Warburg effect”,and how the Warburg effect is turned on and off in c...
CEP-33779 antagonizes P-glycoprotein mediated multidrug resistance by inhibiting its transport funct
[会议论文] 作者：shangjun tang,liwu fu,weiqiang chen,
来源：第八届中国肿瘤学术大会暨抗癌药物专业委员会中青年论坛 年份：2014
Objective: The overexpression of specific ATP-binding cassette (ABC) transporters in cancer cells produces multidrug resistance (MDR), which is the major factor contributing to the failure of chemothe...
[期刊论文] 作者：Chaochu Cui,Robert Merritt,Liwu Fu,Zui Pan,,
来源：Acta Pharmaceutica Sinica B 年份：2017
The intracellular calcium ions(Ca~(2+)) act as second messenger to regulate gene transcription,cell proliferation, migration and death. Accumulating evidences h...
[会议论文] 作者：Ting ZHOU,Jingjing DUAN,Feng XU,Liwu FU,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
...
A novel mechanism of transient cellular self-protection against chemotherapeutical drugs via stimula
[会议论文] 作者：Dongjuan Qiao,Xiaokun Wang,Jiye Cai,Liwu Fu,
来源：广东省生物物理学会2013年学术研讨会 年份：2013
ABCB1 (P-gp/MDR1/ABCB1),one of the most important mediator of multidrug resistance (MDR),has been observed as a result of the selective pressure from chemot...
Afatinib enhances the efficacy of conventional chemotherapeutic agents by eradicating cancer stem-li
[会议论文] 作者：Xiaokun Wang,Fang Wang,Hui Zhang,Liwu Fu,
来源：2015医学前沿论坛暨第十四届全国肿瘤药理与化疗学术会议 年份：2015
Background Cancer stem cells (CSC) have garnered significant attention as a therapeutic focus, based on evidence that they may represent an etiologic root of treatment-resistant cells.Indeed, expressi...
[会议论文] 作者：Ting ZHOU,Jingjing DUAN,Liwu FU,Feng XU,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
Multidrug resistance (MDR) is the main obstacle in breast cancer chemotherapy,a reversal reagent with high reversal effect but low toxicity is the hotpot issue at present.Antidepressant fluoxetine (FL...
Afatinib enhances the efficacy of conventional chemotherapeutic agents by eradicating cancer stem-li
[会议论文] 作者：Xiaokun Wang,Jinghong Xu,Fang Wang,Zhencong Huang,Liwu Fu,
来源：第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议 年份：2014
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