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[期刊论文] 作者:Dong YAN,Yuan-dong HU,Song LI,Mao-sheng CHENG,
来源:中国药理学报(英文版) 年份:2004
AIM: To build a model of 3D-structure of H+, K+-ATPase catalytic subunit for theoretical study and anti-ulcer drug design. METHODS: The model was built on the b...
[会议论文] 作者:Hong-Bo Xie,Jian Wang,Yu Sha,Mao-Sheng Cheng,
来源:第七届国际分子模拟与信息技术应用学术会议 年份:2014
The α1β2γ2 gamma-aminobutyric type A receptor (GABAAR) is one of the most widely expressed GABAAR sub-types in the mammalian brain.GABAARs belonging to the Cys-loop superfamily of ligand-gated ion cha...
Some insights into the binding mechanism of the GABAA receptor: a combined docking and MM-GBSA study
[会议论文] 作者:Hong-Bo Xie,Yu Sha,Jian Wang,Mao-Sheng Cheng,
来源:第七届国际分子模拟与信息技术应用学术会议 年份:2014
Gamma-aminobutyric type A receptor (GABAAR) is a member of the Cys-loop family of pentameric ligand gated ion channels (pLGICs).It has been identified as a key target for many clinical drugs.In the pr...
Pharmacophore-based design,synthesis,and biological evaluation of novel 3-((3,4-dichlorophenyl)(4-su
[期刊论文] 作者:Dong-Mei Zhao,Wen-Yan Li,Yu-Fang Shi,Xu-Qiong Xiong,Shuai Song,Chen-Zhou Hao,Mao-Sheng Cheng,Jing-Kang,
来源:Chinese Chemical Letters 年份:2014
Cholesteryl ester transfer protein(CETP) is a plasma glycoprotein that plays an important role in decreasing high-density lipoprotein cholesterol(HDL-C) levels...
[期刊论文] 作者:Hong-Lei Xie,Chun-Chi Liu,Yi-Qun Li,Chang-Lin Bai,Chen-Zhou Hao,Jing Guo,Chang-Qun Luo,Dong-Mei Zhao,Mao-Sheng Cheng,
来源:Chinese Chemical Letters 年份:2017
A novel series of β-propanamide derivatives as inhibitors of cholesteryl ester transfer protein(CETP)were synthesized.Previously,H3(IC_(50) 2 μmol/L) was obse...
[期刊论文] 作者:Xin-yue Ge,Li Pan,Gang Xing,Yong-mei Mo,Rui-juan Xing,Xiao-ran Li,Yu-yang Zhang,Irving W.Wainer,Mao-sheng Cheng,
来源:中国药理学报(英文版) 年份:2019
β-Arrestins are a small family of proteins important for signal transduction at G protein-coupled receptors (GPCRs).β-Arrestins are involved in the desensitiz...
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