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[会议论文] 作者：韩飞,陈江华,Pedro A.Jose,Ines Armando,
来源：中华医学会肾脏病学分会2014年学术年会 年份：2014
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[会议论文] 作者：韩飞,Ines Armando,Pedro A.Jose,陈江华,
来源：浙江省生物医学工程学会肾脏病透析移植分会2015年学术年会 年份：2015
目的：肾内多巴胺系统对维持正常肾功能与血压起重要作用,近期发现多巴胺D2受体(D2R)缺失可激活TGFβ1,导致肾纤维化,但作用通路未明.肾小管上皮细胞凋亡是肾纤维化的重要启动事件.方法：D2R编码基因的单核苷酸多态性(SNPs)在人群中高发,可导致D2R表达与功能下调.本......
[会议论文] 作者：韩飞,Pedro A.Jose,Ines Armando,陈江华,
来源：中华医学会肾脏病学分会2014年学术年会 年份：2014
目的 多巴胺D2 受体基因(Drd2)的常见单核苷酸多态性(SNPs;rs 6276,6277,and 1800497) 可导致多巴胺D2 受体(D2R)表达与功能下降,且携带上述Drd2 SNPs 的人近端肾小管上皮细胞(hRPTCs)中TGFβ1/Smad3/Snail1 通路上调,细胞表达FN-1,Col 1a,vimentin 等增强.本研......
[期刊论文] 作者：曾春雨,杨志伟,吴丽娟,Laureano D.Asico,Robin A.Felder,Pedro A.Jose,,
来源：中华心血管病杂志 年份：2005
目的探讨D3多巴胺受体基因敲除小鼠(D3-/-)高血压产生的机制,以期了解D3多巴胺受体对血压的调节作用。方法以第2代D3-/-小鼠为研究对象,分别对其血压、肾脏尿钠排泄功能、D3...
Regulation of Blood Pressure and Oxidative Stress by the Balance between Dopamine and the Renin-Angi
[会议论文] 作者：Zhiwei YANG,Xing LIU,Xiaoliang JIANG,Rongyan HU,Yuanyuan ZHANG,Yanrong ZHANG,Pedro A.JOSE,
来源：2017第十九届中国科协年会 年份：2017
Humans have dopamine D5 receptors(hD5R)with single nucleotide polymorphisms and diminished function.The negative interaction between D5R and AT1R is involved in the regulation of renal sodium transpor...
[会议论文] 作者：Xiaorong Tan,Jin Cai,Hongmei Ren,Shuo Zheng,Peng Chen,Pedro A.Jose,Lin Zhou,Chunyu Zeng,
来源：Ready for 2018- the 4th China International Forum on Hyperte 年份：2015
Dopamine receptor plays an important role in hypertension by regulation of sodium excretion.Disruption of the D5 receptor results in hypertension with increased activity of the sympathetic nervous sys...
[会议论文] 作者：Yue Chen,Laureano D.Asico,Shuo Zheng,Van Anthony M.Villar,Duofen He,Lin Zhou,Chunyu Zeng,Pedro A.Jose,
来源：Ready for 2018- the 4th China International Forum on Hyperte 年份：2015
Oral NaCl produces a greater natriuresis and diuresis than the intravenous infusion of the same amount of NaCl.Gastrin is the major gastrointestinal hormone taken up by renal proximal tubule (RPT) cel...
[期刊论文] 作者：于长青,石伟彬,杨剑,傅春江,何多芬,Laureano D.Asico,Pedro A.Jose,曾春雨,,
来源：中华高血压杂志 年份：2004
目的肾脏多巴胺和内皮素(ET)系统通过影响近曲小管尿钠排泄在血压调节中发挥重要作用。敲除 ETB 受体基因或 D_3多巴胺受体基因均形成盐敏感性高血压小鼠,并伴有尿钠排泄能力...
[期刊论文] 作者：杨剑,于长青,石伟彬,傅春江,何多芬,Laureano D.Asico,Pedro A.Jose,曾春雨,,
来源：中华高血压杂志 年份：2008
目的观察多巴胺 D_3受体激动剂对肾脏 G 蛋白亚基 Gα_(12)和 Gα_(13)与 D_3受体耦联的影响。方法以WKY(Wistar-Kyoto)大鼠与自发性高血压大鼠(SHR)及其来源的肾脏皮质膜、...
[期刊论文] 作者：于长青,石伟彬,杨剑,傅春江,何多芬,Laureano D.ASICO,Pedro A.JOSE,曾春雨,,
来源：中华高血压杂志 年份：2008
目的 肾脏多巴胺和内皮素(ET)系统通过影响近曲小管尿钠排泄在血压调节中发挥重要作用.敲除ETB受体基因或D3多巴胺受体基因均形成盐敏感性高血压小鼠,并伴有尿钠排泄能力降低...
[期刊论文] 作者：杨剑,于长青,石伟彬,傅春江,何多芬,Pedro A.Jose,ZENG Chun-yu,曾春雨,,
来源：中华高血压杂志 年份：2008
目的 观察多巴胺D3受体激动剂对肾脏G蛋白亚基Galz和Ga13与D3受体耦联的影响. 方法 以WKY(Wistar-Kyoto)大鼠与自发性高血压大鼠(SHR)及其来源的肾脏皮质膜、肾脏刷状缘膜(BB...
Genome-wide profiling of long noncoding RNA expression patterns in thoracic aorta from spontaneously
[会议论文] 作者：Junyi Yu,Yue Cai,Yukai Liu,Yujia Yang,Yang Chen,Pedro A.Jose,Dazhi Wang,Lin Zhou,Chunyu Zeng,
来源：Ready for 2018- the 4th China International Forum on Hyperte 年份：2015
...
Cardiac-Specific Dopamine D5 Receptor Deficiency Causes Dilated Cardiomyopathy Through ROS Generatio
[会议论文] 作者：Xing LIU,Xiaoliang JIANG,Wenjie WANG,Zihao WANG,Rongyan HU,Yuanyuan ZHANG,Yanrong ZHANG,Pedro A.JOSE,,
来源：2017第十九届中国科协年会 年份：2017
Dilated cardiomyopathy(DCM)is a severe disorder caused by medications or genetic mutations.D5 dopamine receptor(D5R)gene knockout(D5-/-)mice have cardiac hypertrophy and high blood pressure.To investi...
Genome-wide profiling of long noncoding RNA expression patterns in thoracic aorta from spontaneously
[会议论文] 作者：Junyi Yu,Yue Cai,Yukai Liu,Yujia Yang,Yang Chen,Pedro A.Jose,Dazhi Wang,Lin Zhou,Chunyu Zeng,
来源：Ready for 2018- the 4th China International Forum on Hyperte 年份：2015
Objective:Numerous studies have indicated that long non-coding RNAs (IncRNAs) are involved in the cardiovascular development, as well as pathology, such as heart failure and coronary arterial disease....
[会议论文] 作者：Xiaoliang JIANG,Yanrong ZHANG,Yu YANG,Jian YANG,Laureano D.ASICO,Wei CHEN,Robin A.FELDER,Ines ARMANDO,Pedro A.JOSE,
来源：2017第十九届中国科协年会 年份：2017
Gastrin is a peptide hormone that is involved in the regulation of sodium balance and blood pressure.Dopamine,which is also involved in the regulation of sodium balance and blood pressure,directly or...
Tirofiban improves renal outcome in a rat model of ischemia/reperfusion injury by modulating nO synt
[会议论文] 作者：Zhen Wang,Yu Han,Hongmei Ren,Yukai Liu,Xun Kou,Di Yang,Jinjuan Fu,Duofen He,Lin Zhou,Chunyu Zeng,Pedro A.Jose,
来源：2013中国心脏大会(CHC) 年份：2013
...
Prenatal lipopolysaccharide exposure results in dysfunction of the renal dopamine D1 receptor in off
[会议论文] 作者：Xinquan Wang,Hao Luo,Caiyu Chen,Ken Chen,Jialiang Wang,Yue Cai,Shuo Zheng,Xiaoli Yang,Lin Zhou,Pedro A.Jose,
来源：Ready for 2018- the 4th China International Forum on Hyperte 年份：2015
Adverse environment in early life can modulate the adult phenotype, including blood pressure.Lipopolysaccharide (LPS) exposure in utero results in increased blood pressure in the offspring, but the ex...
Tirofiban improves renal outcome in a rat model of ischemia/reperfusion injury by modulating nO synt
[会议论文] 作者：Zhen Wang,Yu Han,Hongmei Ren,Yukai Liu,Xun Kou,Di Yang,Jinjuan Fu,Duofen He,Pedro A.Jose,Lin Zhou,Chunyu,
来源：2013中国心脏大会(CHC) 年份：2013
Aim Renal ischemia/reperfusion (I/R) injury is a co mmon clinical disease.We have known that NO-signal transduction has an important effect on renal I/R injury....
[期刊论文] 作者：于长青,石伟彬,杨剑,张晔,傅春江,何多芬,杨成明,王旭开,Amy J.Mangrum,曾春雨,Pedro A.Jose,,
来源：中华高血压杂志 年份：2007
目的肾脏血管紧张素Ⅱ1型受体(AT1R)的保钠潴水功能部分可以解释AT1R基因敲除(AT1A-/-)小鼠血压降低的原因,然而,对于是否有AT1R以外的机制参与则研究较少。既往的研究间接提...
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