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Discovery of Selective Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors and Biological Evalua
[会议论文] 作者：Sen Ji,Shuang Ma,Wen-Jing Wang,Shen-Zhen Huang,Tian-qi Wang,Rong Xiang,Yi-Guo Hu,Qiang Chen,Lin-Li Li,
来源：第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018) 年份：2018
PRMT5 is an important protein arginine methyltransferase that catalyzes the symmetric dimethylation of arginine resides on histones or non-histone substrate...
From Lead to Drug CandidateOptimization of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Der
[会议论文] 作者：Chun-Hui Zhang,Kai Chen,Yan Jiao,Lin-Li Li,Ya-Ping Li,Rong-Jie Zhang,Ming-Wu Zheng,Lei Zhong,Shen-Zhen Huang,
来源：第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018) 年份：2018
Herein we report the sophisticated process of structural optimization toward a previously disclosed Src inhibitor,compound 1,which showed high potency in th...
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