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CXCR4/CXCL12 Axis Promotes VEGF-Mediated Colorectal Cancer Angiogenesis Through PI3K/Akt and MEK/ERK
[会议论文] 作者：Zhi-Yu Song,Xian-Jun Qu,
来源：首都医科大学第三届研究生学术论坛 年份：2015
Chemokine CXCL12 is an extracellular chemokine which binds to its cell surface receptor CXCR4.High expressions of CXCR4 and CXCL12 are associated with biological malignant potential in colon cancers.H...
[会议论文] 作者：Wenbao Li,Xian-Jun Qu,
来源：全国药物化学学术会议暨第四届中英药物化学学术会议 年份：2013
SL-01,dodecyl-3-((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)pyrazine-2-carboxylate,is an oral gemcitabine derivative synthe...
SL-01,an oral gemcitabine derivative,inhibited the growth of human breast cancer:in vitro and in viv
[会议论文] 作者：Yuan-YuanLi,Yi-Zhuo Qin,Rui-Qi Wang,Xian-Jun Qu,Wen-BaoLi,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
...
Inhibition of acetyl-11-keto-beta-boswellic acid (AKBA) on human colonic carcinoma growth and in com
[会议论文] 作者：Yi Yuan,Xian-Jun Qu,Zu-Hua Gao,Shu-Xiang Cui,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
...
Inhibition of acetyl-11-keto-beta-boswellic acid (AKBA) on human colonic carcinoma growth and in com
[会议论文] 作者：Yi Yuan,Zu-Hua Gao,Shu-Xiang Cui,Xian-Jun Qu,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
Acetyl-11-keto-beta-boswellicacid (AKBA) is a derivative of boswellic acid,which is an active component of the gum resin of Boswellia serrata.We evaluated the effect of AKBA on human colonic carcinoma...
SL-01,an oral gemcitabine derivative,inhibited the growth of human breast cancer:in vitro and in viv
[会议论文] 作者：Yuan-YuanLi,Yi-Zhuo Qin,Rui-Qi Wang,Wen-BaoLi,Xian-Jun Qu,
来源：2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议 年份：2013
Purpose SL-01 is a oral derivative of gemeitabine that was synthesized by introducing the moiety of 3-(dodecyloxycarbonyl)pyrazine-2-carbonyl at the N4-position on the cytidine ring of gemcitabine.We...
Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluor
[期刊论文] 作者：Yu-hang Zhanq,Shu-xiang Cui,Sheng-biao Wan,Shu-hua Wu,Xian-jun Qu,
来源：中国药理学报（英文版） 年份：2021
Sphingosine-1-phosphate(S1P),the backbone of most sphingolipids,activating S1P receptors(S1PRs)and the downstream G protein signaling has been implicated in che...
Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin and its deriv
[会议论文] 作者：Shu-qing WANG,Ye LI,Zhi-yu SONG,Xian-jun QU,Shi-yue SUN,Zu-hua GAO,Shuxiang CUI,
来源：中国药理学会北美分会药理学学术大会 年份：2017
Myricetin is a natural dietary flavonoid compound.We evaluated the efficacy of myricetin and its derivative against intestinal tumorigenesis in adenomatous...
Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin and its deriv
[会议论文] 作者：Ye LI,Shi-yue SUN,Zhi-yu SONG,Shu-qing WANG,Zu-hua GAO,Xian-jun QU,Shuxiang CUI,
来源：中国药理学会北美分会药理学学术大会 年份：2017
Myricetin is a natural dietary flavonoid compound.We evaluated the efficacy of myricetin and its derivative against intestinal tumorigenesis in adenomatous polyposis coli multiple intestinal neoplasia...
[期刊论文] 作者：Xiao-Chun Liu,Jiang-Ming Gao,Shan Liu,Li Liu,Jing-Rui Wang,Xian-Jun Qu,Bing Cai,Shu-Lin Wang,,
来源：World Journal of Translational Medicine 年份：2015
Targeting apoptosis is one of the major strategies for cancer therapy. Essentially, most of the conventional cancer therapeutic drugs that are in the clinical u...
Over-expression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of
[会议论文] 作者：Zhi-yu SONG,Xian-jun QU,Shi-yue SUN,Wen-na SHI,Yu-hang ZHANG,Shu-qing WANG,Xin-fengYU,Shu-xiang CUI,Zu-hua,
来源：中国药理学会北美分会药理学学术大会 年份：2017
The resistance mechanisms that limit the efficacy of retinoid therapy in cancer are poorly understood.Sphingosine kinase 2(SphK2)is a highly conserved enzym...
Over-expression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of
[会议论文] 作者：Wen-na SHI,Shu-xiang CUI,Zhi-yu SONG,Shu-qing WANG,Shi-yue SUN,Xin-fengYU,Yu-hang ZHANG,Zu-hua GAO,Xian-jun QU,
来源：中国药理学会北美分会药理学学术大会 年份：2017
The resistance mechanisms that limit the efficacy of retinoid therapy in cancer are poorly understood.Sphingosine kinase 2(SphK2)is a highly conserved enzyme that is mainly located in the nucleus and...
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