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Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators
[期刊论文] 作者：Shaoyong Lu,Yingyi Chen,Jiacheng Wei,Mingzhu Zhao,Duan Ni,Xinheng He,Jian Zhang,
来源：药学学报（英文版） 年份：2021
The recent discovery of activator compounds binding to an allosteric site on the NAD+-dependent protein lysine deacetylase,sirtuin 6(SIRT6)has attracted interest and presents a pharmaceu-tical target for aging-related and cancer diseases.Ho......
[期刊论文] 作者：Shuyuan Zhang,Qingtai Liang,Xinheng He,Chongchong Zhao,Wenlin Ren,Ziqing Yang,Ziyi Wang,Qiang Ding,Haiteng,
来源：细胞研究（英文版） 年份：2022
Dear Editor,rnSARS-CoV-2 belongs to the Sarbecovirus subgenus of betacor-onaviruses and other members in this subgenus include SARS-CoV and coronaviruses mainly found in bats1....
[期刊论文] 作者：Fulai Zhou,Chenyu Ye,Xiaomin Ma,Wanchao Yin,Tristan I.Croll,Qingtong Zhou,Xinheng He,Xiaokang Zhang,Dehua,
来源：细胞研究（英文版） 年份：2021
Dear Editor,rnVasopressin type 2 receptor(V2R)belongs to the vasopressin(VP)/oxytocin(OT)receptor subfamily of G protein-coupled receptors(GPCRs),which comprises at least four closely related receptor subtypes:V1aR,V1bR,V2R,and OTR.1 These ......
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