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Design and Synthesis of Furano-Pyrimidine Analogs as Aurora Kinase Inhibitors:Optimization of Ligand
[会议论文] 作者：Hui-Yi Shiao,Selvaraj Mohane Coumar,Yi-Yu Ke,Wen-Hsing Lin,John Tsu-An Hsu,Yu-Sheng Chao,Hsing-Pang Hsieh,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
We have recently reported furano-pyrimidine Aurora kinase A inhibitor 3(ligand efficiency,LE=0.25;liphophilic efficiency,LipE=1.75),with potent activity in vitro;however,3 was inactive in vivo.Based o...
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