Necroptosis相关论文
Polygenic risk score for prediction of radiotherapy efficacy and radiosensitivity in patients with n
Objective:Toconstructanovelpolygenicriskscoringmodel,inordertopredictthebenefitsofradiosensitivityinpatientswithnon-meta......
Induction of multiple subroutines of regulated necrosis in murine macrophages by natural BH3-mimetic
Macrophages are critical sentinel cells armed with multiple regulated necrosis pathways,including pyroptosis,apoptosis f......
rStratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIP
Stratifin(SFN)is a member of the 14-3-3 family of highly conserved soluble acidic proteins,which regulates a variety of ......
目的:探讨程序性坏死特异性抑制剂necrostatin-1(Nec-1)对急性高眼压大鼠模型中视网膜神经节细胞(RGCs)程序性坏死的抑制作用。方......
目的:探讨小檗碱对小鼠代谢相关脂肪性肝病（MAFLD）致肝细胞程序性坏死的影响及其相关分子机制。方法:20只雄性C57BL/6N小鼠随机分为4......
目的:评价小檗碱对小鼠非酒精性脂肪性肝病程序性坏死的影响及其与腺苷酸活化蛋白激酶(AMPK)/转录活化因子6(STAT6)通路的关系。方......
Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necropt
Receptor-interacting protein (RIP) kinase 1 is involved in immune-mediated inflammatory diseases including ulcerative co......
Targeted intracellular delivery of shikonin effectively induces osteosarcoma necroptosis with downwa
Osteosarcoma is one of the most common types of primary malignant bone tumors in children and adolescents....
目的：探讨非凋亡的细胞死亡(Necroptosis)及其抑制剂Necrostatin-1(Nec-1)在兔早期激素性股骨头坏死中的作用机制，为股骨头坏死的研......
Objective:The aim of this study was to systematically investigate the role of necroptosis in compression-induced rat nuc......
Targeted intracellular delivery of shikonin effectively induces osteosarcoma necroptosis with downwa
Osteosarcoma is one of the most common types of primary malignant bone tumors in children and adolescents.In this study,......
目的 Ionizing radiation causes long-term injury of hematopoietic stem cells(HSC),however,effective therapeutic protocols......
Augmentation of necroptosis dependent enzymatic activity induces spatial short term memory impairmen
Necroptosis is a novel cell death pathway and Glutamate-ammonia ligase(GLUL)and glutamate dehydrogenase-1(GLUD1)enzymes ......
Endosulfan inducing apoptosis and necroptosis through activation RIPK1 signaling pathway in human um
Endosulfan, an organochlorine pesticide, was found in human blood and its possible cardiovascular toxicity has been sugg......
Role of reactive oxygen species in cobalt chloride-induced cell death and the protective effect of N
Hyperactivated or impaired microglial cells exert neurotoxic effects involved in the pathogenesis of neurological diseas......
Background: Cryptotanshinone(CPT)is a natural compound that has been previously shown to possess antitumor effect agains......
研究背景及目的：脊髓损伤(spinal cord injury,SCI)是脊柱外科常见的急重症,较高的致残率,治疗困难无特效,一直为医学界的攻坚难题.......
Background: Honokiol is a pharmacologically active small molecule with multifunctional antitumor effects.Although plenty......
Silica Nanoparticles Induce the Apoptosis and Necroptosis of Spermatogenic Cells by RIPK1 Signal Pat
Although it is known that nanoparticles is of reproductive toxicity, it is not clear about its mechanism.To investigate ......
RIP1 kinase contributes to neuronal and astrocytic cell death in ischemic stroke via activating auto
Background and Purpose Although the receptor-interacting protein l kinase (RIPIK)-regulated necroptosis can be evoked by......
Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during
Acetaminophen(APAP)overdose induces apoptosis-inducing factor(AIF)-dependent necroptosis,but the mechanism remains obscu......
Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during
Acetaminophen (APAP) overdose induces apoptosis-inducing factor (AIF)-dependent necroptosis,but the mechanism remains ob......
Aim: 3-bromopyruvate (3-BrPA) has antineoplastic activity on malignant cells.In this study, we investigated the toxicity......
Necrosis is an important form of cell demise during organ development and diseases.Traditionally, necrosis has been cons......
In Alzheimers disease (AD), the deposition of amyloid peptides is associated with oxidative stress and inflammatory resp......
Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-
Purpose: Many natural compounds derived from plants or microbes show promising potential for anticancer effect.In this s......
The Targeted Inhibition of Mitochondrial Hsp90 Overcomes The Apoptosis Resistance Conferred By Bcl-2
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Tumor necrosis factor alpha (TNFα) induced mouse fibrosarcoma L929 cell necroptosis by inhibiting p3
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Iridium(Ⅲ)complexes of general formula [Ir(bpy)2(N^N)Cl2],where N^N= 2-(pyrazin-2-yl)naphtho[1,2-e][1,2,4]triazine,1,or......
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URB597 exerts neuroprotective effect against transient cerebral ischemic injury via restor⁃ing autop
OBJECTIVE URB597(KDS-4103)is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase(FAAH)and can ele......
目的探讨第二个线粒体衍生的半胱氨酸蛋白酶激动剂小分子(Smac)类似物LCL161联合天冬氨酸蛋白水解酶(caspase)抑制剂Z-VAD-FMK诱导......
Endosulfan inducing apoptosis and necroptosis through activation RIPK1 in human umbilical vascular e
Epidemiological studies have indicated that persistent organic pollutants (POPs) exposure is most likely relevant to......
The Targeted Inhibition of Mitochondrial Hsp90 Overcomes The Apoptosis Resistance Conferred By Bcl-2
Previous studies presented that Gamitrinibs rapidly accumulate in tumor cell mitochondria, lead cells to apoptotic p......
Cyclometalated Ru(Ⅱ)complex as dual catalytic inhibitors of human Topoisomerase Ⅰ and Ⅱα induce necr
Topoisomerases(Topo)play a key role in the progression of essential cellular processes and have been highlighted as ......
Cationic Peroxidase from Proso Millet Induces Human Colon Cancer Cell Necroptosis by Regulating Auto
Necroptosis is a caspase-independent form of regulated cell death executed by receptor interacting protein kinase 1(......
First story: It is well known that there is always immediate bleeding in spinal cord injury (SCI) and bleeding induc......
调节性坏死是新发现的新型细胞死亡途径，包括程序性坏死、细胞焦亡、铁死亡等。有研究报道，调节性坏死在缺血/再灌注、顺铂等药物、......
混合谱系激酶结构域样蛋白(mixed lineage kinase domain-like protein, MLKL)是一种具有激酶结构域的假激酶，在程序性坏死的调控中......
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目的探究坏死性凋亡相关蛋白大脑中动脉栓塞(MCAO)在脑组织缺血再灌注小鼠脑损伤中的作用及其机制。方法通过大脑中动脉栓塞(MCAO)......
Necroptosis is characterized by programmed necrotic cell death and autophagic activation and might be involved in the de......
颅脑创伤可引起多种类型的细胞发生改变，包括神经元、神经胶质细胞和其他支持细胞等，其中神经元死亡是引起神经系统退化和致死的一个......
疾病的发生往往伴随着炎症反应,并进一步加剧病情,因此炎症研究对疾病的控制和治疗有重要意义.受体相互作用蛋白3(RIP3)是炎症反应......
视网膜脱离(RD)是临床上常见的致盲眼病之一,患者术后视功能恢复不理想.近年来研究表明,光感受器细胞死亡是导致RD后视功能损伤的......
目的探讨程序性坏死特异性抑制剂-1(Nec-1)对脓毒症大鼠肝脏单核细胞趋化蛋白-1(MCP-1)表达的影响及其机制。方法按随机数字表法将......
Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of program......
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Necroptosis作为一种新的半胱氨酸天冬酰胺特异蛋白酶非依赖性的细胞死亡方式,在细胞内环境稳态中扮演重要的角色.necroptosis通过......
