RETIGABINE相关论文
应激性脑损伤是长期持续的心理压力及环境应激导致的脑功能紊乱和脑组织的器质性损伤。脑组织神经元受损是严重失眠、重度抑郁症、......
学位
Antinociceptive Efficacy of Retigabine in the Monosodium Lodoacetate Rat Model for Osteoarthritis Pa
Background: The goal of pharmacological osteoarthritis (OA) treatments is to reduce pain and thus increase patient joint......
Aim To investigate whether Kv7 channels opener retigabine could alleviate memory impairment induced by chronic restraint......
SUMO-specific protease 2 is critical for the regulation of M-current through PLCb4 and Kv7 pathway d
Sudden unexplained death in epilepsy(SUDEP)is the most common and primary cause of premature mortality in epilepsy.Hyper......
Fasudil is a selective and potent RhoA/Rho kinase (ROCK) inhibitor and vasodilator.Since it was discovered, it has been ......
Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor used for the treatment of pain and inflammation.Emerging and......
Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigab
The new antiepileptic drugs perampanel,retigabine,rufinamide and stiripentol have been recently approved for different e......
Sudden unexplained death in epilepsy(SUDEP),which is the most common and primary cause of premature mortality in epi......
Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol,retigabi
The new antiepileptic drugs perampanel,retigabine,rufinamide and stiripentol have been recently approved for different e......
Retigabine(D-23129)为合成的氨基吡啶类似物,具强效抗惊厥活性。本品化学结构式:CAS:150812-12-7药理作用在传统的MES(最大电休克......
Retigabine(D-23129)为合成的氨基吡啶类似物,具强效抗惊厥活性。本品化学结构式:CAS:150812-12-7药理作用在传统的MES(最大电休克......
1980年David Brown博士首次发现了M型乙酰胆碱受体激动剂可以抑制一种钾通道电流,并将其命名为M型钾电流(IM)；十八年后科学家们克隆......
本研究目的是建立可靠的高效液相色谱法测定瑞替加滨及其有关物质.经过色谱条件的优化,采用C18色谱柱(型号:4.6 mm×150 mm,5μm),......
目的改进抗癫痫药瑞替加滨的合成工艺。方法以对硝基苯胺(2)为起始原料,首先与氯甲酸乙酯反应得到N-(4-硝基苯基)氨基甲酸乙酯(3),......
目的:改进抗癫痫药物瑞替加滨的合成工艺。方法:以间氟苯胺为起始原料,经乙酰化、硝化制得N-(5-氟-2-硝基苯基)乙酰胺(3),3与对氟......
...
,Activation of neuronal Kv7/KCNQ/M-channels by the opener Q058-lysine and its anti-nociceptive effec
...
目的探讨瑞替加滨(M型钾离子通道开放剂)对急性脑缺血再灌注损伤的脑保护作用及其可能机制。方法将70只C57BL/6J小鼠按随机数字表......
以氨基化多孔微粒为固相介质，牛血清白蛋白（ BSA）为模型蛋白，通过戊二醛交联反应，制备牛血清白蛋白偶联微球，与药物结合，通过离心沉降微球......
建立瑞替加滨原料药中甲醇、异丙醇、乙酸乙酯残留溶剂的测定方法。以二甲基亚砜(DMSO)为溶剂，DB–WAX123–7032石英毛细管柱为色谱......
目的研究M型钾离子通道开放剂瑞替加滨（retigabine，RTG）对大鼠局灶性缺血再灌注损伤的影响。方法选取SD大鼠110只，随机分为假手术组（10......
对抗癫痫原料药瑞替加滨的合成工艺进行了改进,对硝基苯胺和氯甲酸乙酯为起始原料,为起始原料,经取代、还原、缩合等反应得到目标......
以5-氟-2-硝基苯胺为起始原料，经亲核取代、氢化还原和酰化反应合成了瑞替加滨，并对反应工艺条件进行了优化。中间产物2-氨基4-（4-氟......
建立了测定瑞替加滨原料药中残留溶剂乙醇、正己烷、四氢呋喃、三乙胺的顶空气相色谱方法。采用氢火焰离子化检测器,以N,N-二甲基......
高血压是最常见的慢性心血管疾病，严重的高血压可引起心、脑、肾等多种靶器官的损害，控制高血压是防治心脑血管疾病的关键。因此，研发......
Aim To investigate whether Kv7 channels opener retigabine could alleviate memory impairment induced by chronic restraint......
第一部分海马神经纤维髓鞘损伤在慢性束缚应激抑郁症中的作用目的:在抑郁症的发生发展过程中,海马神经纤维髓鞘会发生怎样的变化,......
