目的 对海洋来源真菌Penicillium sp.产抗肿瘤天然产物brefeldin A进行发酵优化，以期获得高产率目标化合物。方法 运用单因素实验设......

Brefeldin A, a macrolide lactone antibiotic, can block the secretory process in eukaryotic cells by interfering in the e......

Brefeldin A is a secondary metabolite of Ascomycetes species.It was first isolated in 1958 by Singleton from Penicillium......

采用HPLC -MS -MS联用技术 ,分析了C56和C65两株具有抗肿瘤活性的三尖杉植物内生真菌发酵液抽提物 ,首次报道了这两株真菌都能产生......