ripk1相关论文
自身炎症疾病是一类固有免疫系统紊乱的疾病,其特征主要表现为由髓系细胞介导的系统性炎症。遗传因素在自身炎症疾病的发生中起着......
背景:骨关节炎（OA）是一种常见的、与年龄相关的、退化性疾病,其主要特征表现为关节软骨完整性的丧失,关节表面不同程度的骨赘生成,以......
受体相互作用激酶1（receptor-interacting serine/threonine-protein kinase 1,RIPK1）是一种丝氨酸/苏氨酸激酶,在细胞的死亡和炎症......
目的:探讨6-轻基多巴胺氢溴酸盐(6-hydroxydopamine,6-OHDA)诱导帕金森病(parkinson\'s disease,PD)模型小鼠多巴胺能神经元坏死......
细胞程序性坏死(Necroptosis)是一种受控的细胞坏死方式,受体相互作用激酶1(RIPK1)在死亡受体介导的细胞程序性坏死通路中发挥关键......
程序性坏死(Necroptosis)是一种新近发现受调控的细胞坏死,主要依赖于激活后的RIPK1/RIPK3/MLKL等蛋白形成级联复合体并最终导致细......
目的:通过观察帕金森病（Parkinson disease,PD）人血清RIPK1和IL-1β、IL-6、TNF-α的水平变化,评价其对PD的诊断参考价值;探讨PD患者......
自身炎症性疾病是指在没有高滴度自身抗体或抗原特异性T细胞参与的情况下,机体发生非诱发炎症的一类遗传疾病,例如家族性地中海热,......
饥饿应激在哺乳动物新生儿存活、肿瘤微环境及缺血再灌注等一系列生理和病理过程中发挥重要作用.代谢调控对于饥饿条件下细胞及机......
目的：探讨脊髓损后,抑制TNFR/RIPK信号通路对于脊髓损伤(Spinal Cord Injury,SCI)的保护作用,为临床治疗SCI提供新的思路和方向.方......
目的 We aimed to investigate the association between two tag SNP of RIPK1 gene(rs6907943 C/A and rs9392453 C/T)and NSCLC......
Single-nucleotide polymorphism rs17548629 in RIPK1 gene may be associated with lung cancer in a youn
Objective Objective: Genetic biomarkers of lung cancer(LC)susceptibility may provide a basis for treatment and preventio......
Endosulfan inducing apoptosis and necroptosis through activation RIPK1 signaling pathway in human um
Endosulfan, an organochlorine pesticide, was found in human blood and its possible cardiovascular toxicity has been sugg......
Silica Nanoparticles Induce the Apoptosis and Necroptosis of Spermatogenic Cells by RIPK1 Signal Pat
Although it is known that nanoparticles is of reproductive toxicity, it is not clear about its mechanism.To investigate ......
目的探究女贞苷对脑卒中大鼠脑损伤的影响及其作用机制。方法采用大脑中动脉闭塞(MCAO)法建立缺血性脑中风大鼠模型,Longa评分法评......
Endosulfan inducing apoptosis and necroptosis through activation RIPK1 in human umbilical vascular e
Epidemiological studies have indicated that persistent organic pollutants (POPs) exposure is most likely relevant to......
目的 :探讨应用坏死性凋亡抑制剂Necrostatin-1(Nec-1)抑制TNFR/RIPK介导的坏死性凋亡信号通路对大鼠急性脊髓损伤(spinal cord in......
研究背景及目的程序性细胞死亡是一种受基因调控的细胞死亡方式,长期以来,凋亡被认为是程序性细胞死亡的唯一形式。相比之下,坏死......
本论文分为两部分:第一部分:近些年来,细胞程序性坏死已经被认为是一种可控的细胞死亡方式,而且它与多种炎症疾病有关。目前针对细......
[研究背景]肝纤维化是多种慢性肝病的共同病理过程,是慢性肝病发展成肝硬化甚至肝癌的基础和必经阶段,对其有效的防治仍是医学界的......
RIP1 promotes proliferation through G2/M checkpoint progression and mediates cisplatin-induced apopt
Receptor-interacting protein 1 (RIP1,also known as RIPK1) is not only a tumor-promoting factor in several cancers but al......
目的:探讨FLT3-ITD突变的急性髓系白血病(acute myeloid leukemia,AML)患者丝氨酸/苏氨酸激酶1(receptor interacting serine/thre......
Objective: The miR-497 promotes proliferation and migration in MHCC97L cells. Methods: After 24 h transfected with miR-Z......
细胞死亡对于多细胞生物体的发育和自稳平衡起着至关重要的作用。细胞凋亡是生理情况下最主要的程序性细胞死亡方式,而细胞坏死曾......
以非小细胞肺癌A549细胞为模型,探究藻蓝蛋白抑制其增殖和迁移的调控机制。采用MTT法、克隆形成试验、流式细胞术、划痕试验等方法......
目的：探讨miR-497促进肝癌MHCC97L细胞坏死作用机制。方法：（1）质粒转染miR-497,经H2O2诱导后,Annexin V-FITC/PI双染流式分析肝癌细胞......
ue＊M＃’＃dkB4＃＃8＃”专利申请号:00109“7公开号:1278062申请日:00.06.23公开日:00.12.27申请人地址:（100084川C京市海淀区清华园申请人:清......
Objective:The miR-497 promotes proliferation and migration in MHCC97L cells.Methods:After 24 h transfected with miR-Zip ......
<正>机体内大多数细胞要经历分裂、分化、衰老和死亡的过程[1]。在发育和各种刺激的过程中,细胞死亡对于多细胞生物的生存至关重要......
急性肾损伤(Acute kidney injury,AKI)主要以增加的炎症反应和肾脏固有细胞的破坏为特征,进而造成肾脏功能的急剧紊乱。正常肾脏组......
目的研究受体相互作用蛋白激酶1(receptor-interacting protein kinase 1,RIPK1)抑制糖皮质激素(glucocorticoid,GC)体外诱导的间......
程序性细胞坏死(necroptosis/programmed necrosis)是一种caspase非依赖性的程序性细胞死亡方式,因其能被小分子化合物Necrostatin......
