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Objectives To investigate the clinical features of tuberculosis (TB)-associated immune reconstitution inflammatory syndrome (TB-IRIS) in patients co-infected with HIV/TB or latent infection during highly active antiretroviral therapy (HAART).Methods HIV-infected patients were divided into 3 groups: HIV/TB co-infection group (n =50), HIV/MTB latent infection group (n =50), and HIV infection group (n =50), with 12-month follow-up.