癌生物学研究面临的概念性挑战

来源 :2013浦江妇科肿瘤学国际论坛 | 被引量 : 0次 | 上传用户：baby_xiaojuan

【摘要】

：

1.基因组的镶嵌性:同一个人,存在多个基因组Genome Mosaicism—One Human,Multiple Genomes (J.Lupski,Science,2013,341:358-359)胚胎发育中,细胞分裂时发生:染色体非整倍体

【作者】

：

顾健人

【机构】

：

上海市肿瘤研究所

【出处】

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2013浦江妇科肿瘤学国际论坛

【发表日期】

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2013年12期

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论文部分内容阅读

1.基因组的镶嵌性:同一个人,存在多个基因组Genome Mosaicism—One Human,Multiple Genomes (J.Lupski,Science,2013,341:358-359)胚胎发育中,细胞分裂时发生:染色体非整倍体(Aneuploidy)基因拷贝数改变(CNV)基因重组(Gene rearrangement)单核苷多态性(SNP)其普遍性有待更广泛深入的研究如果属普遍性:以前工作的"对照组"存在问题,不同器官/组织的基因差异与疾病是否有关.

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癌生物学研究面临的概念性挑战

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