Epilepsy is a common neurologic affection characterized by excessive temporary neuronal discharge that affects about 1%of the worlds population.Despite the vailability of many antiepileptic drugs(AEDs),there is still an urgent need for the development of more effective and safer AEDs,since about 30%of epileptic patients are not seizure-free with the existing AEDs.1 We designed and synthesized new N-3-amino substituted 5,5-cyclopropanespirohydantoins 5a–r,(Scheme 1)2 Penytoin and ethosuximide are selected as reference drugs.These new hydantoin analogues were found to possess anti-convulsant activity slightly greater than Penytoin.