【摘 要】
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Recent studies on enzymes regulating dynamic N6-methyl-adenosine (m6A) in RNA together with the findings from m6A-methylated RNA immunoprecipitation followed by high-throughput sequencing (MeRIP-seq/m
【出 处】
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2015 Genomics Frontiers Symposium(2015基因组学前沿研讨会)
论文部分内容阅读
Recent studies on enzymes regulating dynamic N6-methyl-adenosine (m6A) in RNA together with the findings from m6A-methylated RNA immunoprecipitation followed by high-throughput sequencing (MeRIP-seq/m6A-seq) have revealed a broad biological role of m6A in RNA processing, development,differentiation, metabolism, and fertility.RNA m6A methylation is catalyzed by a multicomponent methyltransferase complex composed of at least three subunits: METTL3, METTL14, and WTAP, in which METTL3 and METTL14 serve as catalytic subunits while WTAP as regulatory subunit.Dioxygenases FTO and ALKBH5, as the first two known m6A demethylases, catalyze m6A removal.Five m6A binding proteins are classified into cytoplasmic YTH domain-containing family YTHDF1-3 and nuclear YTHDC1-2.
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