Molecular modeling of the Candida albicans Vps4 and a virtual screening study for novel inhibitors

来源 :2013年第四届全国“跨学科蛋白质研究”学术讨论会 | 被引量 : 0次 | 上传用户：lzxhno

【摘要】

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【作者】

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陈亨野余浩源黄欢李万杰杨冬

【机构】

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北京师范大学生物化学与分子生物学系基因工程与生物技术北京市重点实验室,北京100875

【出处】

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2013年第四届全国“跨学科蛋白质研究”学术讨论会

【发表日期】

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2013年2期

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　　Candida albicans is an opportunistic human pathogen.Emergence of drug resistant strains makes it necessary to develop new anti-Candida drugs.Vps4 is an AAA ATPase critical for the function of the ESCRT system.Studies have shown that the deletion of Vps4 is sufficient to abolish the pathogenicity of Candida albicans.

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Molecular modeling of the Candida albicans Vps4 and a virtual screening study for novel inhibitors

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