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To explore the relation between missense mutation of presinilin-l(ps-1)E318G and Alzheimerdisease(AD) in a han Chinese population from hunan, China.Select in March 20l1 to September 2011 in Hunan Province Alzheimers disease a total of 45 cases over the same period from the hospitalized non-Alzheimers disease healthy elderly subjects a total of 48 cases for study.