Experimental and theoretical study on the allostericregulation of an oligomeric protease from Pyroco

来源 :第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会 | 被引量 : 0次 | 上传用户：dragon890123

【摘要】

：

　　The oligomeric thermophilic intracellular protease from Pyrococcus horikoshii (PH1704) is allosterically regulated by Cl-, which acts as the allosteric inhi

【作者】

：

Dongling Zhan Jiao Sun Yawei Song Zesheng Li Weiwei Han Yan Feng

【机构】

：

CollegeofFoodScienceandEngineering,JilinAgriculturalUniversity,130118Changchun,ChinaNormanBethuneCol

【出处】

：

第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会

【发表日期】

：

2013年5期

【关键词】

：

oligomeric protease (PH 1704) allosteric regulation molecular dynamics simulatio

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　The oligomeric thermophilic intracellular protease from Pyrococcus horikoshii (PH1704) is allosterically regulated by Cl-, which acts as the allosteric inhibitor.This study is the first to observe that Clused as the allosteric inhibitor yields with appreciable changes in the catalytic activity of the protease.

其他文献

Isogarcinol is a New Immunosuppressant

　　Calcineurin (CN), a unique protein phosphatase, plays an important role in immune regulation.In this study we used CN as a target enzyme to investigate the

会议

isogarcinolcalcineurinimmunosuppressivedelayed type hypersensitivityallogene

The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL

tRNAs play central roles in protein synthesis by transfer amino acids to ribosome.Nucleotides in tRNA are often post-transcriptionally modified, especially resi

会议

Epoxyeicosatrienoic Acids (EETs) inhibit cardiac hypertrophy via Peroxisome Proliferator-Activated R

Background Epoxyeicosatrienoic Acids (EETs) are the metabolites of arachidonic acid by Cytochrome P450 (CYP) epoxygenases, which have a diverse range of effects

会议

Visualizing GroELES in the Act of Encapsulating a Folding Protein

The GroEL/ES chaperonin system is required for the assisted folding of many proteins.How these substrate proteins are encapsulated within the GroEL-GroES cavity

会议

Protein phosphorylation regulates amino-acid-induced mTORC 1 signaling and cell growth

Abstract: Protein phosphorylation is the most widespread type of post-translational modification used in signal transduction.It can be achieved through the phos

会议

Protein phosphorylationAmino acidsmTORPP2AMAPK3

Multipoint Targeting of the PI3KmTOR Pathway in Mesothelioma

Mesothelioma is a notoriously chemotherapy-resistant neoplasm, as is evident in the dismal overall survival for patients with this asbestos-associated disease.W

会议

Interaction of Pathogenic Proteins in Helicobacter pylori

Helicobacter pylori (H.pylori) ,an infectious bacterium, is known to provoke atrophic gastritis and carcinoma of stomach.The type Ⅳ secretion system expressed

会议

人脑型肌酸激酶二体解离和活性关系的研究

人脑型肌酸激酶(Human brain type creatine kinase,hBCK)主要存在于大脑和视网膜上,并与脑部的质子泵有关.而神经元细胞的绝大部分能量都被Na+-Ka+ATP泵和ATP门控-Ka+通道用

会议

骨架蛋白p62结合对蛋白激酶Cξ活力影响的酶动力学研究

　　蛋白激酶Cζ(PKCξ)是蛋白激酶C家族的成员之一,属于非典型PKC(aPKC)的一种.有报道指出PKCξ能够利用其N端PB1结构域和骨架蛋白p62结合,并参与调控NF-κB信号通路.PKCξ

会议

蛋白激酶Cξp62酶动力学研究

Genome-wide functional screening identifies CDC37 as a crucial HSP90-cofactor for KIT oncogenic expr

Most gastrointestinal stromal tumors (GISTs) contain KIT or PDGFRA kinase gain-of-function mutations, and therefore respond clinically to imatinib and other tyr

会议

CDC37HSP90GISTtargeted therapyfunctional genomicsshRNA library

Experimental and theoretical study on the allostericregulation of an oligomeric protease from Pyroco

与本文相关的学术论文