【摘 要】
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Backgroud: MicroRNAs are a class of endogenous non-coding small RNA, which can regulate gene expression through specific degradation of mRNAs or inhibiting
【机 构】
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Research Center for Laboratory Animal Science of Inner Mongolia University, Hohhot 010070,China
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Backgroud: MicroRNAs are a class of endogenous non-coding small RNA, which can regulate gene expression through specific degradation of mRNAs or inhibiting its translation in post-transcriptional levels.MicroRNA let-7 family was first discovered in C.elegans where it regulates development, cellular proliferation and differentiation.Our previous study indicates that let-7f decrease in miscarriage decidua.Therefore, we hypothesize that let-7f is likely to involve in early pregnancy maintenance by regulating the expression of insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP-1).
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