Virtual Screening Targeting G-Quadruplex DNA: RET-20T

来源 :第八届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户:pausecn
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  G-Quadruplex, differing from other DNA structures like duplex structures, hairpin, triplex, and i-motif structures, is formed by human DNA sequences that consist of tandem guanine (G) nucleotides folding into a four-stranded structure via Hoogsteen hydrogen bonding.
其他文献
With the occurrence of the vancomycin-resistant staphylococcus, the last defense line of bacterial diseases is on the verge of collapse.In an effort to develop novel antibacterial agents against the a
研究安全有效的基因载体己成为基因治疗成功的最重要因素之一.目前,PEI25 kDa被认为是聚合物类非病毒基因转染载体的"黄金标准",但是高的毒性抑制了它的应用.与之相对,小分子PEI的毒性很低,但是转染效率却非常低,也不能很好的用作基因载体.将小分子PEI通过可降解化学键进行桥联是提高其转染效率并保持低细胞毒性的有效方法.
Palladium, a key transition metal in advancing modern organic synthesis, mediates diverse chemical conversions including many carbon-carbon bond formation reactions between organic compounds.However,
The nanoscale size and unique optical properties of semiconductor quantum dots (QDs) have made attractive as central photoluminescent scaffolds for a variety of biosensing platforms.
The widely conserved MarR family of transcription factors modulate bacterial detoxification in response to diverse antibiotics and/or toxic chemicals.The natural inducer for Escherichia coli MarR, the
The imbalance expressing of Cu/Zn superoxide dismutase (SOD1) in vivo will cause intracellular oxygen reduction signal to disorder, which leads to cell proliferation, tumorigensis and damage motorneur
红曲是我国特色的微生物资源.近年来,红曲霉以其众多的次级代谢产物及明确的药用价值,如抗代谢综合症、抗癌症等,受到越来越多研究者的关注.台湾大学潘子明教授课题组发现红曲霉发酵产物具有抗阿尔茨海默病(Alzheimers disease,AD)的药用价值,可延缓病程恶化,并有改善记忆学习的功效.
Polypeptide drugs cause increasing attention due to their application in clinical treatment.On the one hand, many linear peptides have good stability and biological activity in vitro, they degradate r
The PDBbind database is created to provide a comprehensive collection of the binding data for the biomolecular complexes deposited in the Protein Data Bank (PDB).It thus provides a link between energe
A series of novel halogenated 1-benzyl-1-ethyl-3-phenylthiourea derivatives were synthesized by reacting isothiocyanatobenzene and some halogenated N-benzylethanamine.All these compounds have been cha