G-Quadruplex相关论文
富G碱基的DNA序列在离子诱导下可形成G-四链体(G4),基于这一构型转化设计了大量的传感检测平台.其中的荧光检测平台是基于G4与荧光......
Singlet Oxygen Manipulation by Aptamer Functionalized Upconversion Nanocarrier for Targeted Cancer T
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Accumulated evidence showed that the apoptosis which is induced by ruthenium complexes play a key role in inhibiting the......
A label-free ultrasensitive fluorescence detection of viable Salmonella enteritidis by NMM/G-quadrup
The harm of Salmonella enteritidis(S.enteritidis)to public health mainly by contaminating fresh food and water emphasize......
Objective The genome holds extraordinary information.However,only 1.5%or less of mammalian genomes consist of protein-co......
Thrombin-binding DNA aptamer(TBA)can fold into an G-quadruplex structure necessary for interacting with thrombin.It is r......
G-quadruplex are nucleic acid sequences that are rich in guanine and are capable of forming a four-stranded structure, f......
Tumor has become a serious threat to human health and life.Thus,it is of great significance to search for low toxic and ......
A comparative study on human telomeric DNA G-quadruplex binding of meso-5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin......
Assay of uracil–DNA glycosylase(UDG)activity is a crucial step for understanding some fundamental biochemical processes......
Telomerase has become one of the most typical tumor marker because it is closely related to cancers.In this paper,a simp......
Inhibition of Cancer Cell Proliferation and Migration via Benzoxazinone Derivatives Downregulating c
Benzoxazinone derivatives are small molecules with antiplatelet aggregation and antiviral and anticancer properties....
Direct Measurement of Sequential Folding Pathway and Energy Landscape of Human Telomeric G-quadruple
Single stranded guanine-rich sequences fold into compact G-quadruplexes.Although G-triplexes have been proposed and demo......
It has been shown that G-rich DNA can fold into G-quadruplex with a variety of monovalent and divalent metal cations.Her......
Proximity hybridization mediated isothermal exponential amplification for ultrasensitive electrochem
In this work,we fabricated a novel electrochemical biosensing platform on the basis of proximity hybridization triggered......
细胞中RNA处于一种动态变化的过程中。对于实时检测RNA中G-4的状态,对于了解RNA的代谢过程有着重要意义。在综合学习前人的研究基......
PT-OP35:Spectroscopic Evidence of Human Telomeric G-quadruplex Formed from Duplex under near Physiol
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Design,synthesis and anticancer activity of 1,8-naphthalimide-uridine conjugates by targeting telome
G-quadruplex is formed in specific G-rich sequences such as telomere 3-overhang and the promoter of oncogenes....
Acting as anoutstanding biochemical material,DNA is endowed withamazing advantages for the construction of biochemical l......
In the first part,we will introduce our recent work about the role of ribose G-quartets and how they affect the properti......
G-Quadruplex, differing from other DNA structures like duplex structures, hairpin, triplex, and i-motif structures, is f......
Comparative Study on Catechins and Flavonols Binding with Amyloid-β-Peptide,DNA and RNA G-quadruplex
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Synthesis and Evaluation of Acridine Derivatives as a New Class of Selectively Ligands to Binding c-
The nuclease hypersensitivity element (NHE) Ⅲ1 upstream of the P1 promoter that controls 85-90% of the human c-myc prom......
Guanine-rich oligonucleotides being able to self-associate to form G-quadruplex, However, all the G-quadruplex structure......
Nucleic acids containing repetitive tandem guanines can fold into G-quadruplex (G4) motif, which are prevalent in human ......
Synthesis and DNA-binding studies of novel small molecules targeting human telomeric G-quadruplex DN
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Highly Effective Colorimetric and Visual Identification of Tetrastigma hemsleyanum Using an Peroxida
Tetrastigma hemsleyanum Diels et Gilg (Vitaceae) is a rare and endangered perennial herb native to China....
Direct Detection of Blood Potassium Based on Ion-selective induced Formations of Intermolecular G-qu
G-quadruplex analogues have been widely used as an effective tool for fluorescent sensing of potassium ion (K+) ....
A Rapid Three-Dimensional Microfluidic Mixer for Tracking Early Folding Kinetics of G-Quadruplex und
Rapid mixing of high viscosity solutions is crucial for tracking the folding kinetics of macromolecules under molecular ......
Suppression of PD-1 gene overexpression by thio-heterocyclic naphthalimides mediating apoptosis of c
Programmed cell death-1 (PD-1) is a member of the CD28 superfamily, which has been demonstrated to have essential roles ......
Specific Recognition of Quindoline Derivatives on Promoter G-Quadruplex and the Biological Relevance
G-quadruplexes are unique secondary structure exist in various non-coding region of human genome and exhibit important b......
A Highly Sensitive and Selective Optical Sensor for Pb2+ by Using Conjugated Polymers and Label-free
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G-Quadruplexes(GQs),which are formed by G-rich DNA sequences in human telomeres,have become an attractive target for can......
G-quadruplex(G4)is one of the most important secondary structures in nucleic acids[1].Our bioinformatics analysis re......
Recent studies have demonstrated that many biological important processes are related to the conformation and assemb......
The expression of TEM drug-resistance gene in Pseudomonas.Aeruginosa regulated by G-quadruplex struc
Pseudomonas.Aeruginosa is one kind of bacteria which always exist in patients with severe and complicated infection.......
Our previous studies suggest that different forms of DNA could act as an accelerating template in the wild-type Cu/Zn su......
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Discovery of Novel Anti-tumour Agents for Specific Recognizing the G-quadruplex in 5-Untranslated Re
Angiogenesis is important in tumorigenesis and tumor progress.Human vascular endothelial growth factor(hVEGF)is an a......
RNA G-quadruplexes(RG4s)are secondary structures known to influence RNA post-transcriptional mechanisms and have bee......
The Application of Two Fluorescence Sensors in Thrombin Detection Base on The Specific Recognition o
The DNA aptamer TBA can fold into an intramolecular anti-parallel G-quadruplex structure with all reported cations o......
会议
2-(4-Hydroxyphenyl)imidazo[4,5-f ][1,10]phenanthroline derivatives as G-quadurplex DNA-targeting mol
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设计了12条能与血晶素相互作用形成DNA酶的寡核苷酸链,并研究了它们催化4种不同底物[2,2-联氮基双（3-乙基苯并噻唑林-6-磺酸）二铵盐......
The use ofaptamers in bioanalytical and biomedical applications exploits their ability to recognize cell surface protein......
固定化酶相较于游离的酶有贮存稳定性高、活力强、回收易等一系列优点。因此,人们很早之前就对酶的固定化展开了研究。最开始是单......
G-quadruplexes (GQs) are guanine-rich, non-canonical nucleic acid structures that play fundamental roles in biolog-ical ......
DNA酶中的G-四链体-血红素(G4-hemin)DNA酶结构具有较高的设计性和化学稳定性,因此格外受研究者关注.G-平面作为辅酶因子hemin的结......
G-quadruplexes are higher-order nucleic acid structures formed in G-rich sequences in DNA or RNA. G-quadruplexes are dis......
