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  5. Targeted hepatoma chemotherapy in vivo using galactose-decorated crosslinked pH-sensitive degradable

Targeted hepatoma chemotherapy in vivo using galactose-decorated crosslinked pH-sensitive degradable

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：aoli668
【摘 要】
：
The successful cancer chemotherapy relies on the development of smart nanocarriers that are highly stable in circulation,preferentially accumulate in the tumor,are selectively taken up by cancerous ce
【作 者】
：
Yan Zou Weijing Yang Fenghua Meng Zhiyuan Zhong 
【机 构】
：
Biomedical Polymers Laboratory,and Jiangsu Key Laboratory of Advanced Functional Polymer Design and
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
pH-sensitive crosslinked micelles galactose hepatoma targeting 
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　　The successful cancer chemotherapy relies on the development of smart nanocarriers that are highly stable in circulation,preferentially accumulate in the tumor,are selectively taken up by cancerous cells,and quickly release drugs inside the target cells [1].To this end,we have developed galactose-decorated photo-crosslinked pH-sensitive degradable micelles (Gal-CLMs) by co-selfassembly of poly(ethylene glyeol)-b-poly(mono-2,4,6-trimethoxy benzylidene-pentaerythritol carbonate-co-acryloyl carbonate) (PEG-b-P(TMBPEC-co-AC) and Gal-PEG-b-polyε-caprolactone)(Gal-PEG-b-PCL) for active targeting chemotherapy of hepatoma in vivo [2].
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