【摘 要】
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Purpose MiRNA-218 (miR-218) was reported in various human tumors, which could play a role of the occurrence and development of tumor.Our study intends to identify the expression and function of miR-21
【机 构】
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Department of Obstetrics and Gynecology,The First Affiliated Hospital of Nanjing Medical University
【出 处】
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中华医学会第十四次全国妇科肿瘤学术会议
论文部分内容阅读
Purpose MiRNA-218 (miR-218) was reported in various human tumors, which could play a role of the occurrence and development of tumor.Our study intends to identify the expression and function of miR-218 in ovarian tumor.Methods Twenty-five ovarian cystadenoma samples, six borderline ovarian tumor samples and fifty-nine ovarian carcinoma samples that were undergone surgical resection at the First Affiliated Hospital with Nanjing Medical University between 2008 and 2012.
其他文献
Object Drug resistance remains a major clinical obstacle to successful treatment in ovarian cancer patients, and the evidence of microRNAs involvement in drug resistance has been emerging recently.In
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目的 上皮性卵巢癌是死亡率最高的妇科恶性肿瘤.其浆乳癌发病率最高而透明细胞癌预后最差.近年发现,晚期浆乳癌病人年龄越大预后越差.目前miRNA已被誉为最有希望的靶性诊断,个体治疗与疾病预后的标志物.本研究拟探讨透明细胞癌与晚期老年浆乳癌在miRNA表达方面的异同,其与患者预后的关系,及病人存活率方面的标记物作用.方法 从病人手术切除的卵巢癌标本中提取总RNA(Ambion),测定RNA质量后(Ag
目的 探讨上调子宫内膜癌细胞系HEC-1A中胰岛素样生长因子结合蛋白相关蛋白1的表达对子宫内膜癌细胞系HEC-1A增殖,凋亡及细胞周期的影响.方法 采用脂质体介导重组质粒转染HEC-1A细胞,按不同处理分为实验组(转染pEX-2-IGFBP7)、阴性对照组(转染pEX-2-Empty)、空白对照组(只加转染试剂),应用qRT-PCR技术检测各组细胞中IGFBP-rP1 mRNA的表达水平,利用蛋白
Purpose The chemokine receptor 4 (CXCR4) is involved in many malignant tumors and play an important role in growth, angiogenesis and metastasis of various cancers including epithelial ovarian cancer (
目的 对子宫内膜腺癌的高危人群以及子宫内膜腺癌患者进行雌激素与代谢相关研究,寻找发生子宫内膜腺癌的预警标志,预防及防止子宫内膜腺癌的发生.方法 选取广西医科大学附属肿瘤医院首诊子宫内膜腺癌住院患者68例为内膜癌组,对照组51例,检测TC、TG、HDL-C、LDL-C、性激素、空腹血糖、空腹血清胰岛素及计算胰岛素抵抗指数,分析子宫内膜腺癌患者TC、TG、HDL-C、LDL-C与E2、其他代谢性指标、
Purpose Firstly, to purify and proteomic analysis of exosomes from ovarian cancer cell lines.Secondly, to isolate and identify the ascites-derived exosomes from ovarian cancer patients.Thirdly, to exp
目的 评价子宫内膜细胞学检查诊断子宫内膜癌及癌前病变的准确性,评价子宫内膜细胞采集器在子宫内膜细胞学检查中的取材满意度,探讨其作为子宫内膜癌筛查工具的临床应用价值.方法 北大医院行子宫内膜细胞学筛查患者2069例,采用液基薄层细胞学技术制片.以分段诊刮的组织病理诊断为金标准,计算子宫内膜细胞学诊断子宫内膜癌的总符合度、灵敏度、特异度、阳性预测值和阴性预测值.(2)上述研究对象中的114例,采集内膜
Objective To extract exosomes from breast cancer cell line MDA-MB-231 and to analyze their origin and molecular biological characteristics.Methods Exosomes were isolated from breast cancer cells by mu
目的 研究中药单体莪术醇对人卵巢癌SKOV3细胞中JAK2和STAT3蛋白表达的影响,进而探讨中药莪术醇治疗卵巢癌的分子机制,以期为临床莪术醇的运用提供理论依据.方法 根据前期研究MTT检测,将常规培养的SKOV3细胞培养24小时后随机分成5组:对照组(N);顺铂组;莪术醇低剂量(25ug/ml)刺激组;莪术醇中剂量(50ug/ml)刺激组;莪术醇高剂量(100ug/ml)刺激组,分别作用12小时