Disruption of phosphoinositide-specific phospholipases Cγ1 contributes to extracellular matrix synth

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Osteoarthritis (OA) is a degenerative joint disease.Here, we investigated the role of PLCγ1 in human OA progression.Human normal and OA chondrocytes and cartilage were obtained from patients, and the expression level and regulatory mechanism of PLCγ1 were detected.
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