Total Synthesis of Grassystatin A,a Probe for Cathepsin E Function

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：ReganCai

【摘要】

：

【作者】

：

Siming Yang Wei Zhang Ning Ding Jeannette Lo Yanxia Liu Michael J.Clare-Salzler Hendrik Luesch Yingxia Li

【机构】

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School of Pharmacy,Fudan University,Shanghai 201203

【出处】

：

第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

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　　Cathepsin E(cath E) is an intracellular aspartic protease that is mainly present in the immune system.Cath E is highly homologous to the analogous aspartic protease cathepsin D(cath D).So far,the physiological function of cath E has not been completely understood and a wide variety of inhibitors are used to study it.Because of the non-specificity and difficulty in purification or preparation,none of them are available in quantities suffiicient for functional studies.

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Total Synthesis of Grassystatin A,a Probe for Cathepsin E Function

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