【摘 要】
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Aim: To explore the effects of pioglitazone on the levels of TNF-a, IL-6 and BDNF in hippocampus of obese rats induced by ovariectomized and high-fat diet.Methods: Thirty female Wistar rats, age 3 mon
【机 构】
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Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzh
论文部分内容阅读
Aim: To explore the effects of pioglitazone on the levels of TNF-a, IL-6 and BDNF in hippocampus of obese rats induced by ovariectomized and high-fat diet.Methods: Thirty female Wistar rats, age 3 months were randomly divided into three groups: the sham operation fed with normal diet group(group A), ovariectomy plus high-fat diet group(group B),and ovariectomy plus high-fat diet and treated with pioglitazone(group C).3 months later, the blood was collected from the femoral artery to detect the serum FBG, TC, TG, LDL-C HDL-C and insulin,then HOMA-IR was calculated.The levels of TNF-a,IL-6 and BDNF in hippocampus tissue were detected by ELISA.
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