【摘 要】
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The aim of our study is to evaluate the efficacy and safety of endothelial progenitor cells (EPCs) transplantation and glucagon-like peptide 1 (GLP-1) receptor agonist intervention on hindlimb ischemi
【机 构】
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Department of Endocrinology the People's Hospital of Hunan Province, First Affiliated Hospital of H
论文部分内容阅读
The aim of our study is to evaluate the efficacy and safety of endothelial progenitor cells (EPCs) transplantation and glucagon-like peptide 1 (GLP-1) receptor agonist intervention on hindlimb ischemia of diabetic rats.We established the acute hind limb ischemia on SD rats with diabetes mellitus.Diabetic SD rats with hind limb ischemia (n=80) were divided into 7 groups for transplantation.Group A1 (n=10): EPCs transplantion and GLP-1 receptor agonist intervention.Group AO (n=10): EPCs transplantation.Group B1 (n=12): bone marrow mononuclear cells transplantation and GLP-1 receptor agonist intervention.Group BO (n=12): bone marrow mononuclear cells transplantation.Group Cl (n=12): normal saline and GLP-1 receptor agonist intervention.
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