【摘 要】
：
Osteosarcoma is a common malignant bone cancer in children and adolescents.In modern treatments,different chemotherapeutics drugs are administered combined either intravenously or orally both before a
【机 构】
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Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of S
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
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Osteosarcoma is a common malignant bone cancer in children and adolescents.In modern treatments,different chemotherapeutics drugs are administered combined either intravenously or orally both before and after surgery [1].Doxorubicin·hydrochloride (DOX·HCl),a broad-spectrum anti-tumor drug,has shown to be effective in osteosarcoma treatment.Additionally,gene therapy has been an emerging targeted therapeutic strategy for osteosarcoma treatment.For instance,polo-like kinase 1 (PLK1) gene has been chosen as a promising therapeutic target for osteosarcoma therapy,due to its involvement in carcinogenesis.Nevertheless,reports on the co-delivery of anti-tumor drugs and genes for combination cancer treatment through a localized and sustained strategy,such as by using biodegradable and injectable hydrogels,are still limited to-date [2,3].
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