The difficulty of spinal cord injury (SCI) regeneration is primarily caused by the weak endogenous neural,glial scar formation,cystic cavitation,lesion axonal growth and the presence of an unfavorable microenvironment.The complex factors currently lead to no widely accepted treatment options and a variety of therapeutic effects is not very satisfactory [1].Microspheres and threedimensional (3D) biodegradable hydrogels as universal scaffolds exhibit a fascinating application prospect in the field of controlled drug delivery and regenerative medicine [2].Simultaneously,plenty of neurobiology studies suggest that neurotrophins 3 (NT-3) is able to improve the regeneration of axonal nerves in SCI,especially in terms of promoting ascending sensory axonal regeneration and inducing axonal sprouting in the corticospinal tract injury location [3].