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Objective: To discuss the safety and clinical value of multi endoscopic technique combined with cryoscalpel and 2 micron continuous wave laser in treating male urethra stricture.Methods: We retrospectively analyzed the clinical effects of multi-endoscopic technique combined with cryoscalpel and 2 micron continuous wave laser in the treatment of 32 cases of male urethra stricture.Patients were followed up 6-24 months after operation and the effects were observed.Results: All the operations were successfully accomplished and urethra was unobstructed after the catheter was removed.After the operations,the urinary flow rate was remarkably increased from(3.9±2.5)mL/s to(29.5±9.3)mL/s(P<0.05).Conclusions: Multi-endoscopic technique combined with cryoscalpel and 2 micron continuous wave laser is safe and effective for treatment of male urethra stricture.