Mechanical allodynia and affective behavior are improved by INI-0602, a gap junction hemichannel inh

来源 :中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 | 被引量 : 0次 | 上传用户：februaryliao

【摘要】

：

【作者】

：

ZHANG Xiao-min FAN Li-xia PENG Yue-xia SONG Qi XIANG Yu-ke WU Wei-li WANG Qin TAO Liang

【机构】

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Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080,C

【出处】

：

中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛

【发表日期】

：

2016年11期

【关键词】

：

INI-0602 gap junction hemichannel inhibitor neuropathic pain depression anxiety

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　　OBJECTIVE To investigated the effects of INI-0602 on nociceptive reflex, depression-associated and anxiety-related behaviors caused by neuropathic pain in sciatic nerve injury rats.METHODS Male rat were subjected to sciatic nerve injury (SNI) or sham surgery.Rat received daily treatment with INI-0602 intrathecally, at a dose of 0.25 μg/10 μL.

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Mechanical allodynia and affective behavior are improved by INI-0602, a gap junction hemichannel inh

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