Endoplasmic reticulum (ER) stress is increasingly recognized as an important causal factor of many diseases.Targeting ER stress has now emerged as a new therapeutic strategy for treating cardiovascula
血小板聚集和血栓形成是心脑血管病的主要病因,血小板上有两种主要的ADP受体亚型,即P2Y1和P2Y12.已知P2Y12是抗血小板聚集药物氯毗格雷及类似物的作用靶点,此类药物有很强的抗血小板作用,但容易引起出血的副作用也很明显.因而寻找安全,有效的新型抗血小板药物是心血管药物研发的重要任务.血小板P2Y1受体亚型能否作为抗血小板药物的新靶点仍有待研究.我们借助工具药研究了血小板上这两种受体亚型的信号
OBJECTIVE To investigate the protective effect of salvianolic acid A (Sal A) on isoproterenol-induced myocardial infarction in mice and its possible mechanisms.
Erigeron multiradiatus (Lindl.) Benth., has been used in Tibet folk medicine to treat various inflammatory diseases.The aim of this study was to investigate anti-myocardial ischemia and reperfusion (I
OBJECTIVE To investigate the role of adventitial vasa vasorum in artery remodeling during the process of pulmonary artery hypertension (PAH) , we checked the small heat shock protein 27/25 (HSPB1) whe
OBJECTIVE To investigate the effect of hydrogen-rich saline on platelet activation in hypertensive rats.METHODS The male Wistar rats were divided into control group, hypertension group, control + hydr
OBJECTIVE To explore whether J24924 could prevent the development of pristane-induced lupus in a mouse model, and whether it could protect renal and lower the cardiovascular risk.
OBJECTIVE Urocortins (UCNs) and transforming growth factor-3 (TGF-β) have been demonstrated to participate in various cardiovascular diseases, many of which involve VSMCs proliferation.
OBJECTIVE Here we investigated the effects and the underlying mechanism of Ginkgolide K (1,10-dihydroxy-3, 14-didehydroginkgolide, GK) on cardiac ER stress.
OBJECTIVE The greatest challenge in chemotherapy of ischemic stroke is the construction a suitable delivery system to overcome the poor physicochemical properties of drug and its low permeability acro